Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp

ABSTRACT Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public health (B. pseudomallei) and biosecu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Robert J. Hogan, Eric R. Lafontaine
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Burkholderia glanders humoral immunity melioidosis vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b5f0b1b1d85f4c0fbf7a32537492663d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5f0b1b1d85f4c0fbf7a32537492663d
record_format	dspace
spelling	oai:doaj.org-article:b5f0b1b1d85f4c0fbf7a32537492663d2021-11-15T15:22:05ZAntibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp10.1128/mSphere.00674-182379-5042https://doaj.org/article/b5f0b1b1d85f4c0fbf7a32537492663d2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00674-18https://doaj.org/toc/2379-5042ABSTRACT Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public health (B. pseudomallei) and biosecurity (B. mallei) threats. In this issue of mSphere, an article by Khakhum and colleagues (N. Khakhum, P. Bharaj, J. N. Myers, D. Tapia, et al., mSphere 4:e00570-18, 2019, https://doi.org/10.1128/mSphere.00570-18) describes a novel vaccination platform with excellent potential for cross-protection against both Burkholderia species. The report also highlights the importance of antibodies in immunity against these facultative intracellular organisms.Robert J. HoganEric R. LafontaineAmerican Society for MicrobiologyarticleBurkholderiaglandershumoral immunitymelioidosisvaccinesMicrobiologyQR1-502ENmSphere, Vol 4, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Burkholderia glanders humoral immunity melioidosis vaccines Microbiology QR1-502
spellingShingle	Burkholderia glanders humoral immunity melioidosis vaccines Microbiology QR1-502 Robert J. Hogan Eric R. Lafontaine Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
description	ABSTRACT Burkholderia pseudomallei and Burkholderia mallei are the causative agents of melioidosis and glanders, respectively. There is no vaccine to protect against these highly pathogenic bacteria, and there is concern regarding their emergence as global public health (B. pseudomallei) and biosecurity (B. mallei) threats. In this issue of mSphere, an article by Khakhum and colleagues (N. Khakhum, P. Bharaj, J. N. Myers, D. Tapia, et al., mSphere 4:e00570-18, 2019, https://doi.org/10.1128/mSphere.00570-18) describes a novel vaccination platform with excellent potential for cross-protection against both Burkholderia species. The report also highlights the importance of antibodies in immunity against these facultative intracellular organisms.
format	article
author	Robert J. Hogan Eric R. Lafontaine
author_facet	Robert J. Hogan Eric R. Lafontaine
author_sort	Robert J. Hogan
title	Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
title_short	Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
title_full	Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
title_fullStr	Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
title_full_unstemmed	Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp
title_sort	antibodies are major drivers of protection against lethal aerosol infection with highly pathogenic <italic toggle="yes">burkholderia</italic> spp
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/b5f0b1b1d85f4c0fbf7a32537492663d
work_keys_str_mv	AT robertjhogan antibodiesaremajordriversofprotectionagainstlethalaerosolinfectionwithhighlypathogenicitalictoggleyesburkholderiaitalicspp AT ericrlafontaine antibodiesaremajordriversofprotectionagainstlethalaerosolinfectionwithhighlypathogenicitalictoggleyesburkholderiaitalicspp
_version_	1718428093194960896

Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic <italic toggle="yes">Burkholderia</italic> spp

Ejemplares similares