Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Abstract For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) an...

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Autores principales:	Mohammad Souri, Madjid Soltani, Farshad Moradi Kashkooli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5f2d95cc3b248a09f8c836a0ae6293c
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spelling	oai:doaj.org-article:b5f2d95cc3b248a09f8c836a0ae6293c2021-12-02T17:37:40ZComputational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors10.1038/s41598-021-98554-z2045-2322https://doaj.org/article/b5f2d95cc3b248a09f8c836a0ae6293c2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98554-zhttps://doaj.org/toc/2045-2322Abstract For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) and its encapsulation have been investigated in this study. Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast ( $$\gamma -{Fe}_{2}{O}_{3}$$ γ - Fe 2 O 3 ) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.Mohammad SouriMadjid SoltaniFarshad Moradi KashkooliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Souri Madjid Soltani Farshad Moradi Kashkooli Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
description	Abstract For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) and its encapsulation have been investigated in this study. Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast ( $$\gamma -{Fe}_{2}{O}_{3}$$ γ - Fe 2 O 3 ) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.
format	article
author	Mohammad Souri Madjid Soltani Farshad Moradi Kashkooli
author_facet	Mohammad Souri Madjid Soltani Farshad Moradi Kashkooli
author_sort	Mohammad Souri
title	Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
title_short	Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
title_full	Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
title_fullStr	Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
title_full_unstemmed	Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
title_sort	computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5f2d95cc3b248a09f8c836a0ae6293c
work_keys_str_mv	AT mohammadsouri computationalmodelingofthermalcombinationtherapiesbymagnetoultrasonicheatingtoenhancedrugdeliverytosolidtumors AT madjidsoltani computationalmodelingofthermalcombinationtherapiesbymagnetoultrasonicheatingtoenhancedrugdeliverytosolidtumors AT farshadmoradikashkooli computationalmodelingofthermalcombinationtherapiesbymagnetoultrasonicheatingtoenhancedrugdeliverytosolidtumors
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Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

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