Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodis...

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Autores principales:	Tingbao Ning, Yangjian Zhou, Haixia Xu, Shiri Guo, Ke Wang, Deng-Guang Yu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	orodispersible membranes coaxial electrospinning poorly water-soluble drug core-sheath nanofibers Chemical technology TP1-1185 Chemical engineering TP155-156
Acceso en línea:	https://doaj.org/article/b5f5189c3f0a43df9b0580b447f80d74
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spelling	oai:doaj.org-article:b5f5189c3f0a43df9b0580b447f80d742021-11-25T18:19:27ZOrodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium10.3390/membranes111108022077-0375https://doaj.org/article/b5f5189c3f0a43df9b0580b447f80d742021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/802https://doaj.org/toc/2077-0375The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodispersible membrane (OM) comprising electrospun nanofibers is developed for the fast dissolution of diclofenac sodium (DS). A modified coaxial electrospinning was implemented for the preparation of membranes, during which an unspinnable solution of sucralose was explored as the sheath working fluid for smoothing the working processes and also adjusting the taste of membranes. SEM and TEM images demonstrated that the OMs were composed of linear nanofibers with core-sheath inner structures. XRD and ATR-FTIR results suggested that DS presented in the OMs in an amorphous state due to the fine compatibility between DS and PVP. In vitro dissolution measurements and simulated artificial tongue experiments verified that the OMs were able to release the loaded DS in a pulsatile manner. The present protocols pave the way for the fast dissolution and fast action of a series of poorly water-soluble active ingredients that are suitable for oral administration.Tingbao NingYangjian ZhouHaixia XuShiri GuoKe WangDeng-Guang YuMDPI AGarticleorodispersible membranescoaxial electrospinningpoorly water-soluble drugcore-sheath nanofibersChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 802, p 802 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orodispersible membranes coaxial electrospinning poorly water-soluble drug core-sheath nanofibers Chemical technology TP1-1185 Chemical engineering TP155-156
spellingShingle	orodispersible membranes coaxial electrospinning poorly water-soluble drug core-sheath nanofibers Chemical technology TP1-1185 Chemical engineering TP155-156 Tingbao Ning Yangjian Zhou Haixia Xu Shiri Guo Ke Wang Deng-Guang Yu Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
description	The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodispersible membrane (OM) comprising electrospun nanofibers is developed for the fast dissolution of diclofenac sodium (DS). A modified coaxial electrospinning was implemented for the preparation of membranes, during which an unspinnable solution of sucralose was explored as the sheath working fluid for smoothing the working processes and also adjusting the taste of membranes. SEM and TEM images demonstrated that the OMs were composed of linear nanofibers with core-sheath inner structures. XRD and ATR-FTIR results suggested that DS presented in the OMs in an amorphous state due to the fine compatibility between DS and PVP. In vitro dissolution measurements and simulated artificial tongue experiments verified that the OMs were able to release the loaded DS in a pulsatile manner. The present protocols pave the way for the fast dissolution and fast action of a series of poorly water-soluble active ingredients that are suitable for oral administration.
format	article
author	Tingbao Ning Yangjian Zhou Haixia Xu Shiri Guo Ke Wang Deng-Guang Yu
author_facet	Tingbao Ning Yangjian Zhou Haixia Xu Shiri Guo Ke Wang Deng-Guang Yu
author_sort	Tingbao Ning
title	Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
title_short	Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
title_full	Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
title_fullStr	Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
title_full_unstemmed	Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium
title_sort	orodispersible membranes from a modified coaxial electrospinning for fast dissolution of diclofenac sodium
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b5f5189c3f0a43df9b0580b447f80d74
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Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

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