Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction

Abstract ACS patients with renal dysfunction tend to have a poorer prognosis than those with normal renal function. This retrospective cohort study was performed using The Second Drug-Eluting Stent Impact on Revascularization Registry, a retrospective registry, to evaluate the time-dependent relativ...

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Autores principales:	Xiaojia Zhang, Liangping Hu, Wen Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5f539ff2ec54382a8b1f37edb44119c
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spelling	oai:doaj.org-article:b5f539ff2ec54382a8b1f37edb44119c2021-12-02T15:08:27ZPercutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction10.1038/s41598-018-20651-32045-2322https://doaj.org/article/b5f539ff2ec54382a8b1f37edb44119c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20651-3https://doaj.org/toc/2045-2322Abstract ACS patients with renal dysfunction tend to have a poorer prognosis than those with normal renal function. This retrospective cohort study was performed using The Second Drug-Eluting Stent Impact on Revascularization Registry, a retrospective registry, to evaluate the time-dependent relative risk of revascularization strategies in ACS patients with renal dysfunction. The study demonstrated that the short-term MACCE rate was lower after PCI than CABG. However, there was no significant difference in long-term MACCE rate. Subgroup analyses based on the degree of renal dysfunction resulted in similar findings. The revascularization strategy was identified as a time-dependent covariate by the time-dependent Cox model, and the regression coefficient was ‘−1.124 + 0.344 × ln (time + 1)’. For the entire object group and the separate subgroups, PCI was initially associated with a lower hazard for MACCE than CABG after revascularization, then the hazard ratio increases with time. In conclusion, the hazard ratio for MACCE in PCI relative to CABG is time-dependent. PCI tends to have a lower risk for MACCE than CABG in the short-term, then the hazard ratio increases with time.Xiaojia ZhangLiangping HuWen ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaojia Zhang Liangping Hu Wen Zheng Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
description	Abstract ACS patients with renal dysfunction tend to have a poorer prognosis than those with normal renal function. This retrospective cohort study was performed using The Second Drug-Eluting Stent Impact on Revascularization Registry, a retrospective registry, to evaluate the time-dependent relative risk of revascularization strategies in ACS patients with renal dysfunction. The study demonstrated that the short-term MACCE rate was lower after PCI than CABG. However, there was no significant difference in long-term MACCE rate. Subgroup analyses based on the degree of renal dysfunction resulted in similar findings. The revascularization strategy was identified as a time-dependent covariate by the time-dependent Cox model, and the regression coefficient was ‘−1.124 + 0.344 × ln (time + 1)’. For the entire object group and the separate subgroups, PCI was initially associated with a lower hazard for MACCE than CABG after revascularization, then the hazard ratio increases with time. In conclusion, the hazard ratio for MACCE in PCI relative to CABG is time-dependent. PCI tends to have a lower risk for MACCE than CABG in the short-term, then the hazard ratio increases with time.
format	article
author	Xiaojia Zhang Liangping Hu Wen Zheng
author_facet	Xiaojia Zhang Liangping Hu Wen Zheng
author_sort	Xiaojia Zhang
title	Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
title_short	Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
title_full	Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
title_fullStr	Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
title_full_unstemmed	Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction
title_sort	percutaneous coronary intervention versus coronary artery bypass graft in acute coronary syndrome patients with renal dysfunction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b5f539ff2ec54382a8b1f37edb44119c
work_keys_str_mv	AT xiaojiazhang percutaneouscoronaryinterventionversuscoronaryarterybypassgraftinacutecoronarysyndromepatientswithrenaldysfunction AT liangpinghu percutaneouscoronaryinterventionversuscoronaryarterybypassgraftinacutecoronarysyndromepatientswithrenaldysfunction AT wenzheng percutaneouscoronaryinterventionversuscoronaryarterybypassgraftinacutecoronarysyndromepatientswithrenaldysfunction
_version_	1718388145306730496

Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft in Acute Coronary Syndrome patients with Renal Dysfunction

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