Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging

Laser speckle imaging has been an indispensable tool for visualizing blood flow in biomedical applications. We proposed a novel design of the laser speckle imaging system, which combines confocal illumination and detection with various speckle analysis methods. The system can be operated by three im...

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Autores principales:	E Du, Shuhao Shen, Anqi Qiu, Nanguang Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	laser speckle line-scan cardiac blood flow confocal chick embryo Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b5f69b7370a84d64af77d555ef9b392b
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spelling	oai:doaj.org-article:b5f69b7370a84d64af77d555ef9b392b2021-11-25T16:42:09ZLine Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging10.3390/app1122109692076-3417https://doaj.org/article/b5f69b7370a84d64af77d555ef9b392b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10969https://doaj.org/toc/2076-3417Laser speckle imaging has been an indispensable tool for visualizing blood flow in biomedical applications. We proposed a novel design of the laser speckle imaging system, which combines confocal illumination and detection with various speckle analysis methods. The system can be operated by three imaging modes. One is surface illumination laser speckle contrast imaging (SI-LSCI) and the other two are line scan temporal speckle contrast imaging (LS-TSCI) and line scan spatial speckle contrast imaging (LS-SSCI). The experimental results of flow phantoms have validated the mixture model, which combines the Lorentzian and Gaussian models to describe the simultaneous existence of both Brownian motions and ordered flow. Our experimental results of in vivo chick embryos demonstrate that LS-SSCI maintains high temporal resolution and is less affected by motion artifacts. LS-SSCI can provide better image quality for in vivo imaging blood chick embryos than LS-TSCI. Furthermore, the experiential results present that LS-SSCI can detect and quantify the blood flow change during vascular clipping, and shows great potential in diagnosing vascular diseases, such as angiosclerosis, angiostenosis, or angiemphraxis.E DuShuhao ShenAnqi QiuNanguang ChenMDPI AGarticlelaser speckleline-scancardiacblood flowconfocalchick embryoTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10969, p 10969 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laser speckle line-scan cardiac blood flow confocal chick embryo Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	laser speckle line-scan cardiac blood flow confocal chick embryo Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 E Du Shuhao Shen Anqi Qiu Nanguang Chen Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
description	Laser speckle imaging has been an indispensable tool for visualizing blood flow in biomedical applications. We proposed a novel design of the laser speckle imaging system, which combines confocal illumination and detection with various speckle analysis methods. The system can be operated by three imaging modes. One is surface illumination laser speckle contrast imaging (SI-LSCI) and the other two are line scan temporal speckle contrast imaging (LS-TSCI) and line scan spatial speckle contrast imaging (LS-SSCI). The experimental results of flow phantoms have validated the mixture model, which combines the Lorentzian and Gaussian models to describe the simultaneous existence of both Brownian motions and ordered flow. Our experimental results of in vivo chick embryos demonstrate that LS-SSCI maintains high temporal resolution and is less affected by motion artifacts. LS-SSCI can provide better image quality for in vivo imaging blood chick embryos than LS-TSCI. Furthermore, the experiential results present that LS-SSCI can detect and quantify the blood flow change during vascular clipping, and shows great potential in diagnosing vascular diseases, such as angiosclerosis, angiostenosis, or angiemphraxis.
format	article
author	E Du Shuhao Shen Anqi Qiu Nanguang Chen
author_facet	E Du Shuhao Shen Anqi Qiu Nanguang Chen
author_sort	E Du
title	Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
title_short	Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
title_full	Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
title_fullStr	Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
title_full_unstemmed	Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging
title_sort	line scan spatial speckle contrast imaging and its application in blood flow imaging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b5f69b7370a84d64af77d555ef9b392b
work_keys_str_mv	AT edu linescanspatialspecklecontrastimaginganditsapplicationinbloodflowimaging AT shuhaoshen linescanspatialspecklecontrastimaginganditsapplicationinbloodflowimaging AT anqiqiu linescanspatialspecklecontrastimaginganditsapplicationinbloodflowimaging AT nanguangchen linescanspatialspecklecontrastimaginganditsapplicationinbloodflowimaging
_version_	1718413038819737600

Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging

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