Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia

Zemenu Sifr,1 Telto Ando,1 Wosenyeleh Semeon,1 Muse Rike,1 Kidist Ashami2 1Department of Health Information Technology, Hawassa College of Health Sciences, Hawassa, Ethiopia; 2Harvard Graduate School of Arts and Science, Boston, MA, 02138, USACorrespondence: Zemenu SifrDepartment of Health Informati...

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Autores principales:	Sifr Z, Ando T, Semeon W, Ashami K, Rike M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lost to follow-up attrition hiv-infected children art and sidama zone Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b5f86d95f602472d820b002418dc1608
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spelling	oai:doaj.org-article:b5f86d95f602472d820b002418dc16082021-12-02T16:26:57ZLevel of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia1179-1373https://doaj.org/article/b5f86d95f602472d820b002418dc16082021-08-01T00:00:00Zhttps://www.dovepress.com/level-of-attrition-from-antiretroviral-therapy-among-human-immune-defi-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Zemenu Sifr,1 Telto Ando,1 Wosenyeleh Semeon,1 Muse Rike,1 Kidist Ashami2 1Department of Health Information Technology, Hawassa College of Health Sciences, Hawassa, Ethiopia; 2Harvard Graduate School of Arts and Science, Boston, MA, 02138, USACorrespondence: Zemenu SifrDepartment of Health Information Technology, Hawassa College of Health Sciences, P.O. Box 84, Hawassa, EthiopiaEmail sifrezemenu2020@gmail.comBackground: Human immune deficiency virus (HIV) remains one of the leading causes of infectious disease mortality and morbidity in Sub-Saharan Africa. Although remarkable progress has been made in prevention and treatment of HIV, there is a higher rate of loss to follow-up in HIV-infected children than in adults, once they enter care.Objective: To determine the incidence and identify predictors of loss to follow-up among HIV-infected children on anti-retroviral treatment in Sidama Zone, Ethiopia.Methods: A retrospective cohort study was done among children that were enrolled in ART care in Sidama Zone from September 2014 to August 2018. A total of 143 eligible children were included in this study. A structured checklist was used to extract data from patients’ medical records such as patient intake forms, electronic database, and registers. Data were entered, cleaned, coded, and analyzed by STATA version 12. Cox proportional hazards models were fitted to investigate predictors of loss to follow-up.Results: Of the 143 participants, 76 (53.15%) were female children with a median age of 7 years and interquartile range of 4– 9. The incidence rate was 5 per 100 person-years and the cumulative incidence 12.59%. The median follow-up time was 2.46 years and the total time at risk was 356.06 person-years. Furthermore, 55.56% and 72.22% of those lost to follow-up were within the first and the second years of follow-up, respectively. In multivariable Cox proportional model, only the TB status of the children was significantly associated with loss to follow-up with hazard ratio 3.348 [1.174831, 9.543494] and p-value of 0.024.Conclusion: In this study, TB status of children was the significant determinant of loss to follow-up. However, the overall retention was 87.4% and a substantially higher proportion of loss was observed within the first and second years of follow-up.Keywords: lost to follow-up, attrition, HIV-infected children, ART, Sidama zoneSifr ZAndo TSemeon WAshami KRike MDove Medical Pressarticlelost to follow-upattritionhiv-infected childrenartand sidama zoneImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 813-822 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lost to follow-up attrition hiv-infected children art and sidama zone Immunologic diseases. Allergy RC581-607
spellingShingle	lost to follow-up attrition hiv-infected children art and sidama zone Immunologic diseases. Allergy RC581-607 Sifr Z Ando T Semeon W Ashami K Rike M Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
description	Zemenu Sifr,1 Telto Ando,1 Wosenyeleh Semeon,1 Muse Rike,1 Kidist Ashami2 1Department of Health Information Technology, Hawassa College of Health Sciences, Hawassa, Ethiopia; 2Harvard Graduate School of Arts and Science, Boston, MA, 02138, USACorrespondence: Zemenu SifrDepartment of Health Information Technology, Hawassa College of Health Sciences, P.O. Box 84, Hawassa, EthiopiaEmail sifrezemenu2020@gmail.comBackground: Human immune deficiency virus (HIV) remains one of the leading causes of infectious disease mortality and morbidity in Sub-Saharan Africa. Although remarkable progress has been made in prevention and treatment of HIV, there is a higher rate of loss to follow-up in HIV-infected children than in adults, once they enter care.Objective: To determine the incidence and identify predictors of loss to follow-up among HIV-infected children on anti-retroviral treatment in Sidama Zone, Ethiopia.Methods: A retrospective cohort study was done among children that were enrolled in ART care in Sidama Zone from September 2014 to August 2018. A total of 143 eligible children were included in this study. A structured checklist was used to extract data from patients’ medical records such as patient intake forms, electronic database, and registers. Data were entered, cleaned, coded, and analyzed by STATA version 12. Cox proportional hazards models were fitted to investigate predictors of loss to follow-up.Results: Of the 143 participants, 76 (53.15%) were female children with a median age of 7 years and interquartile range of 4– 9. The incidence rate was 5 per 100 person-years and the cumulative incidence 12.59%. The median follow-up time was 2.46 years and the total time at risk was 356.06 person-years. Furthermore, 55.56% and 72.22% of those lost to follow-up were within the first and the second years of follow-up, respectively. In multivariable Cox proportional model, only the TB status of the children was significantly associated with loss to follow-up with hazard ratio 3.348 [1.174831, 9.543494] and p-value of 0.024.Conclusion: In this study, TB status of children was the significant determinant of loss to follow-up. However, the overall retention was 87.4% and a substantially higher proportion of loss was observed within the first and second years of follow-up.Keywords: lost to follow-up, attrition, HIV-infected children, ART, Sidama zone
format	article
author	Sifr Z Ando T Semeon W Ashami K Rike M
author_facet	Sifr Z Ando T Semeon W Ashami K Rike M
author_sort	Sifr Z
title	Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
title_short	Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
title_full	Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
title_fullStr	Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
title_full_unstemmed	Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia
title_sort	level of attrition from antiretroviral therapy among human immune deficiency virus-infected children: the cases of sidama zone, southern ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b5f86d95f602472d820b002418dc1608
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Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia

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