Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.
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Nature Portfolio
2016
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oai:doaj.org-article:b5fefa9e561b4571b7f90454d487e1a72021-12-02T15:35:25ZEssential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope10.1038/ncomms110842041-1723https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a72016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11084https://doaj.org/toc/2041-1723CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.Petra MikolcevicMichitaka IsodaHiroki ShibuyaIvan del Barco BarrantesAna IgeaJosé A. SujaSue ShackletonYoshinori WatanabeAngel R. NebredaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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Science Q Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
description |
CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes. |
format |
article |
author |
Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda |
author_facet |
Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda |
author_sort |
Petra Mikolcevic |
title |
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
title_short |
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
title_full |
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
title_fullStr |
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
title_full_unstemmed |
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope |
title_sort |
essential role of the cdk2 activator ringoa in meiotic telomere tethering to the nuclear envelope |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a7 |
work_keys_str_mv |
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