Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.

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Bibliographic Details
Main Authors:	Petra Mikolcevic, Michitaka Isoda, Hiroki Shibuya, Ivan del Barco Barrantes, Ana Igea, José A. Suja, Sue Shackleton, Yoshinori Watanabe, Angel R. Nebreda
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a7
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id	oai:doaj.org-article:b5fefa9e561b4571b7f90454d487e1a7
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spelling	oai:doaj.org-article:b5fefa9e561b4571b7f90454d487e1a72021-12-02T15:35:25ZEssential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope10.1038/ncomms110842041-1723https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a72016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11084https://doaj.org/toc/2041-1723CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.Petra MikolcevicMichitaka IsodaHiroki ShibuyaIvan del Barco BarrantesAna IgeaJosé A. SujaSue ShackletonYoshinori WatanabeAngel R. NebredaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
description	CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.
format	article
author	Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda
author_facet	Petra Mikolcevic Michitaka Isoda Hiroki Shibuya Ivan del Barco Barrantes Ana Igea José A. Suja Sue Shackleton Yoshinori Watanabe Angel R. Nebreda
author_sort	Petra Mikolcevic
title	Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
title_short	Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
title_full	Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
title_fullStr	Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
title_full_unstemmed	Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
title_sort	essential role of the cdk2 activator ringoa in meiotic telomere tethering to the nuclear envelope
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a7
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Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

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