Nanomedicine as an emerging approach against intracellular pathogens

Andrea L Armstead1&ndash;3, Bingyun Li1&ndash;31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, WV; 2Pharmaceutical and Pharmacological Sciences, Health Sciences Center, West Virginia Uni...

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Autores principales:	Armstead AL, Li B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b60781975189455b8a923d4f19caa661
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spelling	oai:doaj.org-article:b60781975189455b8a923d4f19caa6612021-12-02T07:45:06ZNanomedicine as an emerging approach against intracellular pathogens1176-91141178-2013https://doaj.org/article/b60781975189455b8a923d4f19caa6612011-12-01T00:00:00Zhttp://www.dovepress.com/nanomedicine-as-an-emerging-approach-against-intracellular-pathogens-a8838https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Andrea L Armstead1&ndash;3, Bingyun Li1&ndash;31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, WV; 2Pharmaceutical and Pharmacological Sciences, Health Sciences Center, West Virginia University, Morgantown, WV; 3WVNano Initiative, Morgantown, WV, USAAbstract: Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen&#39;s intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases.Keywords: intracellular pathogen, infection, nanomedicine, nanoparticle, drug deliveryArmstead ALLi BDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3281-3293 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Armstead AL Li B Nanomedicine as an emerging approach against intracellular pathogens
description	Andrea L Armstead1&ndash;3, Bingyun Li1&ndash;31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, WV; 2Pharmaceutical and Pharmacological Sciences, Health Sciences Center, West Virginia University, Morgantown, WV; 3WVNano Initiative, Morgantown, WV, USAAbstract: Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen&#39;s intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases.Keywords: intracellular pathogen, infection, nanomedicine, nanoparticle, drug delivery
format	article
author	Armstead AL Li B
author_facet	Armstead AL Li B
author_sort	Armstead AL
title	Nanomedicine as an emerging approach against intracellular pathogens
title_short	Nanomedicine as an emerging approach against intracellular pathogens
title_full	Nanomedicine as an emerging approach against intracellular pathogens
title_fullStr	Nanomedicine as an emerging approach against intracellular pathogens
title_full_unstemmed	Nanomedicine as an emerging approach against intracellular pathogens
title_sort	nanomedicine as an emerging approach against intracellular pathogens
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/b60781975189455b8a923d4f19caa661
work_keys_str_mv	AT armsteadal nanomedicineasanemergingapproachagainstintracellularpathogens AT lib nanomedicineasanemergingapproachagainstintracellularpathogens
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Nanomedicine as an emerging approach against intracellular pathogens

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