Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment

Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment

Bone marrow engraftment of haematopoietic stem and progenitor cells (HSPCs) requires homing and lodgement to the niche. Here, the authors show that mDia2 is required for HSPC polarization, nuclear MAL, and SRF-induced beta2 integrin expression during transendothelial migration of HSPCs required for...

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Autores principales: Yang Mei, Xu Han, Yijie Liu, Jing Yang, Ronen Sumagin, Peng Ji
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b6098e9eea144499bb9d476ae3f84f10
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spelling oai:doaj.org-article:b6098e9eea144499bb9d476ae3f84f102021-12-02T18:02:42ZDiaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment10.1038/s41467-020-16911-42041-1723https://doaj.org/article/b6098e9eea144499bb9d476ae3f84f102020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16911-4https://doaj.org/toc/2041-1723Bone marrow engraftment of haematopoietic stem and progenitor cells (HSPCs) requires homing and lodgement to the niche. Here, the authors show that mDia2 is required for HSPC polarization, nuclear MAL, and SRF-induced beta2 integrin expression during transendothelial migration of HSPCs required for engraftment.Yang MeiXu HanYijie LiuJing YangRonen SumaginPeng JiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Mei
Xu Han
Yijie Liu
Jing Yang
Ronen Sumagin
Peng Ji
Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
description Bone marrow engraftment of haematopoietic stem and progenitor cells (HSPCs) requires homing and lodgement to the niche. Here, the authors show that mDia2 is required for HSPC polarization, nuclear MAL, and SRF-induced beta2 integrin expression during transendothelial migration of HSPCs required for engraftment.
format article
author Yang Mei
Xu Han
Yijie Liu
Jing Yang
Ronen Sumagin
Peng Ji
author_facet Yang Mei
Xu Han
Yijie Liu
Jing Yang
Ronen Sumagin
Peng Ji
author_sort Yang Mei
title Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
title_short Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
title_full Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
title_fullStr Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
title_full_unstemmed Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
title_sort diaphanous-related formin mdia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b6098e9eea144499bb9d476ae3f84f10
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AT xuhan diaphanousrelatedforminmdia2regulatesbeta2integrinstocontrolhematopoieticstemandprogenitorcellengraftment
AT yijieliu diaphanousrelatedforminmdia2regulatesbeta2integrinstocontrolhematopoieticstemandprogenitorcellengraftment
AT jingyang diaphanousrelatedforminmdia2regulatesbeta2integrinstocontrolhematopoieticstemandprogenitorcellengraftment
AT ronensumagin diaphanousrelatedforminmdia2regulatesbeta2integrinstocontrolhematopoieticstemandprogenitorcellengraftment
AT pengji diaphanousrelatedforminmdia2regulatesbeta2integrinstocontrolhematopoieticstemandprogenitorcellengraftment
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