Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice

Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice

NLRP3 inflammasome activation contributes to several pathogenic conditions, including lipopolysaccharide (LPS)-induced sickness behavior characterized by reduced mobility and depressive behaviors. Dimethyl fumarate (DMF) is an immunomodulatory and anti-oxidative molecule commonly used for the sympto...

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Bibliographic Details
Main Authors: Bora Tastan, Burak I. Arioz, Kemal Ugur Tufekci, Emre Tarakcioglu, Ceren Perihan Gonul, Kursad Genc, Sermin Genc
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
dimethyl fumarate (DMF)
microglia
NLRP3 inflammasome
lipopolysaccharide (LPS)
sickness behaviors
pyroptosis
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/b60a1794759e426ca70953d604e6e91d
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https://doaj.org/article/b60a1794759e426ca70953d604e6e91d

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