Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepr...

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Autores principales:	Sungjun Park, Seungwon Lee, Choong-Gu Lee, Guk Yeol Park, Hyebeen Hong, Jeon-Soo Lee, Young Min Kim, Sung Bae Lee, Daehee Hwang, Youn Soo Choi, John D. Fryer, Sin-Hyeog Im, Seung-Woo Lee, Yoontae Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc
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spelling	oai:doaj.org-article:b60b97a6a56040e89b56ef95ec263afc2021-12-02T17:06:09ZCapicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV510.1038/ncomms160372041-1723https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16037https://doaj.org/toc/2041-1723Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.Sungjun ParkSeungwon LeeChoong-Gu LeeGuk Yeol ParkHyebeen HongJeon-Soo LeeYoung Min KimSung Bae LeeDaehee HwangYoun Soo ChoiJohn D. FryerSin-Hyeog ImSeung-Woo LeeYoontae LeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sungjun Park Seungwon Lee Choong-Gu Lee Guk Yeol Park Hyebeen Hong Jeon-Soo Lee Young Min Kim Sung Bae Lee Daehee Hwang Youn Soo Choi John D. Fryer Sin-Hyeog Im Seung-Woo Lee Yoontae Lee Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
description	Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.
format	article
author	Sungjun Park Seungwon Lee Choong-Gu Lee Guk Yeol Park Hyebeen Hong Jeon-Soo Lee Young Min Kim Sung Bae Lee Daehee Hwang Youn Soo Choi John D. Fryer Sin-Hyeog Im Seung-Woo Lee Yoontae Lee
author_facet	Sungjun Park Seungwon Lee Choong-Gu Lee Guk Yeol Park Hyebeen Hong Jeon-Soo Lee Young Min Kim Sung Bae Lee Daehee Hwang Youn Soo Choi John D. Fryer Sin-Hyeog Im Seung-Woo Lee Yoontae Lee
author_sort	Sungjun Park
title	Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
title_short	Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
title_full	Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
title_fullStr	Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
title_full_unstemmed	Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
title_sort	capicua deficiency induces autoimmunity and promotes follicular helper t cell differentiation via derepression of etv5
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc
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Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

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