NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance...

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Autores principales: Karthigayan Shanmugasundaram, Bijaya K. Nayak, William E. Friedrichs, Dharam Kaushik, Ronald Rodriguez, Karen Block
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b6112e9eaddb4fcbbe6870525a0bd64f
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spelling oai:doaj.org-article:b6112e9eaddb4fcbbe6870525a0bd64f2021-12-02T15:38:50ZNOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance10.1038/s41467-017-01106-12041-1723https://doaj.org/article/b6112e9eaddb4fcbbe6870525a0bd64f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01106-1https://doaj.org/toc/2041-1723NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance.Karthigayan ShanmugasundaramBijaya K. NayakWilliam E. FriedrichsDharam KaushikRonald RodriguezKaren BlockNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Karthigayan Shanmugasundaram
Bijaya K. Nayak
William E. Friedrichs
Dharam Kaushik
Ronald Rodriguez
Karen Block
NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
description NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance.
format article
author Karthigayan Shanmugasundaram
Bijaya K. Nayak
William E. Friedrichs
Dharam Kaushik
Ronald Rodriguez
Karen Block
author_facet Karthigayan Shanmugasundaram
Bijaya K. Nayak
William E. Friedrichs
Dharam Kaushik
Ronald Rodriguez
Karen Block
author_sort Karthigayan Shanmugasundaram
title NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
title_short NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
title_full NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
title_fullStr NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
title_full_unstemmed NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
title_sort nox4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b6112e9eaddb4fcbbe6870525a0bd64f
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AT williamefriedrichs nox4functionsasamitochondrialenergeticsensorcouplingcancermetabolicreprogrammingtodrugresistance
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