Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells

Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells

Abstract Ageing is a broad cellular process, largely affecting the immune system, especially T-lymphocytes. Additionally to immunosenescence alone, cytomegalovirus (CMV) infection is thought to have major impacts on T-cell subset composition and exhaustion. These impacts have been studied extensivel...

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Bibliographic Details
Main Authors: Martine J. Kallemeijn, Anne Mieke H. Boots, Michèle Y. van der Klift, Elisabeth Brouwer, Wayel H. Abdulahad, Jan A. N. Verhaar, Jacques J. M. van Dongen, Anton W. Langerak
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/b6172dab0f5b443a97beab16c2765c3b
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