A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1

BackgroundPhosphorylated CTD-interacting factor 1 (PCIF1) is identified as the only known methyltransferase of N6,2′-O-dimethyladenosine (m6Am) in mRNA. However, its oncogenic and immunogenic role in cancer research is at an initial stage.MethodsHerein, we carried out a pan-cancer analysis of PCIF1,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ming-Zhu Jin, Yi-Gan Zhang, Wei-Lin Jin, Xi-Peng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PCIF1 N6,2′-O-dimethyladenosine (m6Am) pan-cancer analysis immune checkpoint genes (ICGs) posttranslational modification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b61876cfe3be4ad38268000d15703959
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b61876cfe3be4ad38268000d15703959
record_format	dspace
spelling	oai:doaj.org-article:b61876cfe3be4ad38268000d157039592021-11-30T14:26:58ZA Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF12234-943X10.3389/fonc.2021.753393https://doaj.org/article/b61876cfe3be4ad38268000d157039592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.753393/fullhttps://doaj.org/toc/2234-943XBackgroundPhosphorylated CTD-interacting factor 1 (PCIF1) is identified as the only known methyltransferase of N6,2′-O-dimethyladenosine (m6Am) in mRNA. However, its oncogenic and immunogenic role in cancer research is at an initial stage.MethodsHerein, we carried out a pan-cancer analysis of PCIF1, with a series of datasets (e.g., TIMER2.0, GEPIA2, cBioPortal).ResultsPCIF1 expression was higher in most cancers than normal tissues and was discrepant across pathological stages. Highly expressed PCIF1 was positively correlated with overall survival (OS) or disease-free survival (DFS) of some tumors. PCIF1 expression had a positive correlation with CD4+ T-cell infiltration in kidney renal clear cell carcinoma (KIRC), CD8+ T cells, macrophages, and B cells in thyroid carcinoma (THCA), and immune checkpoint genes (ICGs) in LIHC but a negative correlation with CD4+ T cells, neutrophils, myeloid dendritic cells, and ICGs in THCA. It also affected tumor mutational burden (TMB) and microsatellite instability (MSI) of most tumors.ConclusionPCIF1 expression was correlated with cancer prognosis and immune infiltration, suggesting it to be a potential target for cancer therapy.Ming-Zhu JinYi-Gan ZhangWei-Lin JinXi-Peng WangFrontiers Media S.A.articlePCIF1N6,2′-O-dimethyladenosine (m6Am)pan-cancer analysisimmune checkpoint genes (ICGs)posttranslational modificationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PCIF1 N6,2′-O-dimethyladenosine (m6Am) pan-cancer analysis immune checkpoint genes (ICGs) posttranslational modification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	PCIF1 N6,2′-O-dimethyladenosine (m6Am) pan-cancer analysis immune checkpoint genes (ICGs) posttranslational modification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ming-Zhu Jin Yi-Gan Zhang Wei-Lin Jin Xi-Peng Wang A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
description	BackgroundPhosphorylated CTD-interacting factor 1 (PCIF1) is identified as the only known methyltransferase of N6,2′-O-dimethyladenosine (m6Am) in mRNA. However, its oncogenic and immunogenic role in cancer research is at an initial stage.MethodsHerein, we carried out a pan-cancer analysis of PCIF1, with a series of datasets (e.g., TIMER2.0, GEPIA2, cBioPortal).ResultsPCIF1 expression was higher in most cancers than normal tissues and was discrepant across pathological stages. Highly expressed PCIF1 was positively correlated with overall survival (OS) or disease-free survival (DFS) of some tumors. PCIF1 expression had a positive correlation with CD4+ T-cell infiltration in kidney renal clear cell carcinoma (KIRC), CD8+ T cells, macrophages, and B cells in thyroid carcinoma (THCA), and immune checkpoint genes (ICGs) in LIHC but a negative correlation with CD4+ T cells, neutrophils, myeloid dendritic cells, and ICGs in THCA. It also affected tumor mutational burden (TMB) and microsatellite instability (MSI) of most tumors.ConclusionPCIF1 expression was correlated with cancer prognosis and immune infiltration, suggesting it to be a potential target for cancer therapy.
format	article
author	Ming-Zhu Jin Yi-Gan Zhang Wei-Lin Jin Xi-Peng Wang
author_facet	Ming-Zhu Jin Yi-Gan Zhang Wei-Lin Jin Xi-Peng Wang
author_sort	Ming-Zhu Jin
title	A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
title_short	A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
title_full	A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
title_fullStr	A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
title_full_unstemmed	A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1
title_sort	pan-cancer analysis of the oncogenic and immunogenic role of m6am methyltransferase pcif1
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b61876cfe3be4ad38268000d15703959
work_keys_str_mv	AT mingzhujin apancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT yiganzhang apancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT weilinjin apancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT xipengwang apancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT mingzhujin pancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT yiganzhang pancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT weilinjin pancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1 AT xipengwang pancanceranalysisoftheoncogenicandimmunogenicroleofm6ammethyltransferasepcif1
_version_	1718406527681822720

A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1

Ejemplares similares