A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus

The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting...

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Autores principales:	Mašić Aleksandar, Woldeab Niziti, Embury-Hyatt Carissa, Zhou Yan, Babiuk Shawn
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	h1n1 swine influenza pandemic influenza vaccine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b61a294429db42f4ac897a5e766a0304
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spelling	oai:doaj.org-article:b61a294429db42f4ac897a5e766a03042021-11-17T21:27:52ZA single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus1820-744810.2478/acve-2014-0002https://doaj.org/article/b61a294429db42f4ac897a5e766a03042014-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0002https://doaj.org/toc/1820-7448The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the absence of neutralizing antibodies specific for H1N1 2009 in sera.Mašić AleksandarWoldeab NizitiEmbury-Hyatt CarissaZhou YanBabiuk ShawnSciendoarticleh1n1swine influenzapandemic influenzavaccineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 1, Pp 10-23 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	h1n1 swine influenza pandemic influenza vaccine Veterinary medicine SF600-1100
spellingShingle	h1n1 swine influenza pandemic influenza vaccine Veterinary medicine SF600-1100 Mašić Aleksandar Woldeab Niziti Embury-Hyatt Carissa Zhou Yan Babiuk Shawn A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
description	The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the absence of neutralizing antibodies specific for H1N1 2009 in sera.
format	article
author	Mašić Aleksandar Woldeab Niziti Embury-Hyatt Carissa Zhou Yan Babiuk Shawn
author_facet	Mašić Aleksandar Woldeab Niziti Embury-Hyatt Carissa Zhou Yan Babiuk Shawn
author_sort	Mašić Aleksandar
title	A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
title_short	A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
title_full	A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
title_fullStr	A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
title_full_unstemmed	A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus
title_sort	single dose vaccination with an elastase-dependent h1n1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic h1n1 virus
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/b61a294429db42f4ac897a5e766a0304
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A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus

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