Somatosensory perception–action binding in Tourette syndrome

Abstract It is a common phenomenon that somatosensory sensations can trigger actions to alleviate experienced tension. Such “urges” are particularly relevant in patients with Gilles de la Tourette (GTS) syndrome since they often precede tics, the cardinal feature of this common neurodevelopmental di...

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Autores principales:	Julia Friedrich, Henriette Spaleck, Ronja Schappert, Maximilian Kleimaker, Julius Verrel, Tobias Bäumer, Christian Beste, Alexander Münchau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b61c4c9b461547f993ae04d45a35cd88
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spelling	oai:doaj.org-article:b61c4c9b461547f993ae04d45a35cd882021-12-02T16:32:12ZSomatosensory perception–action binding in Tourette syndrome10.1038/s41598-021-92761-42045-2322https://doaj.org/article/b61c4c9b461547f993ae04d45a35cd882021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92761-4https://doaj.org/toc/2045-2322Abstract It is a common phenomenon that somatosensory sensations can trigger actions to alleviate experienced tension. Such “urges” are particularly relevant in patients with Gilles de la Tourette (GTS) syndrome since they often precede tics, the cardinal feature of this common neurodevelopmental disorder. Altered sensorimotor integration processes in GTS as well as evidence for increased binding of stimulus- and response-related features (“hyper-binding”) in the visual domain suggest enhanced perception–action binding also in the somatosensory modality. In the current study, the Theory of Event Coding (TEC) was used as an overarching cognitive framework to examine somatosensory-motor binding. For this purpose, a somatosensory-motor version of a task measuring stimulus–response binding (S-R task) was tested using electro-tactile stimuli. Contrary to the main hypothesis, there were no group differences in binding effects between GTS patients and healthy controls in the somatosensory-motor paradigm. Behavioral data did not indicate differences in binding between examined groups. These data can be interpreted such that a compensatory “downregulation” of increased somatosensory stimulus saliency, e.g., due to the occurrence of somatosensory urges and hypersensitivity to external stimuli, results in reduced binding with associated motor output, which brings binding to a “normal” level. Therefore, “hyper-binding” in GTS seems to be modality-specific.Julia FriedrichHenriette SpaleckRonja SchappertMaximilian KleimakerJulius VerrelTobias BäumerChristian BesteAlexander MünchauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Friedrich Henriette Spaleck Ronja Schappert Maximilian Kleimaker Julius Verrel Tobias Bäumer Christian Beste Alexander Münchau Somatosensory perception–action binding in Tourette syndrome
description	Abstract It is a common phenomenon that somatosensory sensations can trigger actions to alleviate experienced tension. Such “urges” are particularly relevant in patients with Gilles de la Tourette (GTS) syndrome since they often precede tics, the cardinal feature of this common neurodevelopmental disorder. Altered sensorimotor integration processes in GTS as well as evidence for increased binding of stimulus- and response-related features (“hyper-binding”) in the visual domain suggest enhanced perception–action binding also in the somatosensory modality. In the current study, the Theory of Event Coding (TEC) was used as an overarching cognitive framework to examine somatosensory-motor binding. For this purpose, a somatosensory-motor version of a task measuring stimulus–response binding (S-R task) was tested using electro-tactile stimuli. Contrary to the main hypothesis, there were no group differences in binding effects between GTS patients and healthy controls in the somatosensory-motor paradigm. Behavioral data did not indicate differences in binding between examined groups. These data can be interpreted such that a compensatory “downregulation” of increased somatosensory stimulus saliency, e.g., due to the occurrence of somatosensory urges and hypersensitivity to external stimuli, results in reduced binding with associated motor output, which brings binding to a “normal” level. Therefore, “hyper-binding” in GTS seems to be modality-specific.
format	article
author	Julia Friedrich Henriette Spaleck Ronja Schappert Maximilian Kleimaker Julius Verrel Tobias Bäumer Christian Beste Alexander Münchau
author_facet	Julia Friedrich Henriette Spaleck Ronja Schappert Maximilian Kleimaker Julius Verrel Tobias Bäumer Christian Beste Alexander Münchau
author_sort	Julia Friedrich
title	Somatosensory perception–action binding in Tourette syndrome
title_short	Somatosensory perception–action binding in Tourette syndrome
title_full	Somatosensory perception–action binding in Tourette syndrome
title_fullStr	Somatosensory perception–action binding in Tourette syndrome
title_full_unstemmed	Somatosensory perception–action binding in Tourette syndrome
title_sort	somatosensory perception–action binding in tourette syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b61c4c9b461547f993ae04d45a35cd88
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Somatosensory perception–action binding in Tourette syndrome

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