Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

Abstract This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluo...

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Autores principales:	Shang-Te Ma, Chu-Hsuan Huang, Yun-Chia Chang, Tso-Ting Lai, Yi-Ting Hsieh, Tzyy-Chang Ho, Chung-May Yang, Cheng-Guo Cheng, Chang-Hao Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b61de17dd0a6481f9a6646e38cc3ea3f
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spelling	oai:doaj.org-article:b61de17dd0a6481f9a6646e38cc3ea3f2021-12-02T18:03:06ZClinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography10.1038/s41598-021-97340-12045-2322https://doaj.org/article/b61de17dd0a6481f9a6646e38cc3ea3f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97340-1https://doaj.org/toc/2045-2322Abstract This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for > 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN was assessed using OCTA and divided into three types by a previously described BVN classification: type 1 (trunk), type 2 (glomeruli), and type 3 (stick). At baseline, type 1 BVN had the poorest vision and thinnest subfoveal choroidal thickness (SFCT), whereas type 3 had the best vision and thickest SFCT. The aforementioned trend sustained after treatments. Each BVN morphology in OCTA showed typical features in FA + ICGA and encompassed significant correlation (p = 0.004). In conclusion, OCTA is an innovative imaging tool for the detection and classification of BVN in PCV. Furthermore, OCTA has advantages of being noninvasive and free of systemic toxicities. The BVN can be divided into three types based on morphological characteristics in OCTA, which play crucial roles in clinical presentations and treatment outcomes.Shang-Te MaChu-Hsuan HuangYun-Chia ChangTso-Ting LaiYi-Ting HsiehTzyy-Chang HoChung-May YangCheng-Guo ChengChang-Hao YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shang-Te Ma Chu-Hsuan Huang Yun-Chia Chang Tso-Ting Lai Yi-Ting Hsieh Tzyy-Chang Ho Chung-May Yang Cheng-Guo Cheng Chang-Hao Yang Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
description	Abstract This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for > 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN was assessed using OCTA and divided into three types by a previously described BVN classification: type 1 (trunk), type 2 (glomeruli), and type 3 (stick). At baseline, type 1 BVN had the poorest vision and thinnest subfoveal choroidal thickness (SFCT), whereas type 3 had the best vision and thickest SFCT. The aforementioned trend sustained after treatments. Each BVN morphology in OCTA showed typical features in FA + ICGA and encompassed significant correlation (p = 0.004). In conclusion, OCTA is an innovative imaging tool for the detection and classification of BVN in PCV. Furthermore, OCTA has advantages of being noninvasive and free of systemic toxicities. The BVN can be divided into three types based on morphological characteristics in OCTA, which play crucial roles in clinical presentations and treatment outcomes.
format	article
author	Shang-Te Ma Chu-Hsuan Huang Yun-Chia Chang Tso-Ting Lai Yi-Ting Hsieh Tzyy-Chang Ho Chung-May Yang Cheng-Guo Cheng Chang-Hao Yang
author_facet	Shang-Te Ma Chu-Hsuan Huang Yun-Chia Chang Tso-Ting Lai Yi-Ting Hsieh Tzyy-Chang Ho Chung-May Yang Cheng-Guo Cheng Chang-Hao Yang
author_sort	Shang-Te Ma
title	Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
title_short	Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
title_full	Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
title_fullStr	Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
title_full_unstemmed	Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
title_sort	clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b61de17dd0a6481f9a6646e38cc3ea3f
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Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

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