Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system

The transplantation of tissue-specific progenitor cells may be an approach in organ regeneration. Here the authors show that the nephron progenitor population of a developing mouse kidney, when ablated, can be replaced by exogenously supplied rat nephron progenitors, generating interspecies nephrons...

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Autores principales: S. Yamanaka, S. Tajiri, T. Fujimoto, K. Matsumoto, S. Fukunaga, B. S. Kim, H. J. Okano, T. Yokoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b61fa958ba624c5393de0249d5c0bab0
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Sumario:The transplantation of tissue-specific progenitor cells may be an approach in organ regeneration. Here the authors show that the nephron progenitor population of a developing mouse kidney, when ablated, can be replaced by exogenously supplied rat nephron progenitors, generating interspecies nephrons.