Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites

Alzheimer’s disease (AD) is a neurodegenerative disease that impacts 45 million people worldwide and is ranked as the 6th top cause of death among all adults by the Centers for Disease Control and Prevention. While genetics is an important risk factor for the development of AD, environment and lifes...

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Autores principales:	Dulce M. Frausto, Christopher B. Forsyth, Ali Keshavarzian, Robin M. Voigt
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease microbiota diet SCFA LPS bacterial metabolites Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/b623d3e1db7743b58fb94d88f94bfe83
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spelling	oai:doaj.org-article:b623d3e1db7743b58fb94d88f94bfe832021-11-19T05:39:47ZDietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites1662-453X10.3389/fnins.2021.736814https://doaj.org/article/b623d3e1db7743b58fb94d88f94bfe832021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.736814/fullhttps://doaj.org/toc/1662-453XAlzheimer’s disease (AD) is a neurodegenerative disease that impacts 45 million people worldwide and is ranked as the 6th top cause of death among all adults by the Centers for Disease Control and Prevention. While genetics is an important risk factor for the development of AD, environment and lifestyle are also contributing risk factors. One such environmental factor is diet, which has emerged as a key influencer of AD development/progression as well as cognition. Diets containing large quantities of saturated/trans-fats, refined carbohydrates, limited intake of fiber, and alcohol are associated with cognitive dysfunction while conversely diets low in saturated/trans-fats (i.e., bad fats), high mono/polyunsaturated fats (i.e., good fats), high in fiber and polyphenols are associated with better cognitive function and memory in both humans and animal models. Mechanistically, this could be the direct consequence of dietary components (lipids, vitamins, polyphenols) on the brain, but other mechanisms are also likely to be important. Diet is considered to be the single greatest factor influencing the intestinal microbiome. Diet robustly influences the types and function of micro-organisms (called microbiota) that reside in the gastrointestinal tract. Availability of different types of nutrients (from the diet) will favor or disfavor the abundance and function of certain groups of microbiota. Microbiota are highly metabolically active and produce many metabolites and other factors that can affect the brain including cognition and the development and clinical progression of AD. This review summarizes data to support a model in which microbiota metabolites influence brain function and AD.Dulce M. FraustoChristopher B. ForsythChristopher B. ForsythAli KeshavarzianAli KeshavarzianAli KeshavarzianRobin M. VoigtRobin M. VoigtFrontiers Media S.A.articleAlzheimer’s diseasemicrobiotadietSCFALPSbacterial metabolitesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease microbiota diet SCFA LPS bacterial metabolites Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease microbiota diet SCFA LPS bacterial metabolites Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Dulce M. Frausto Christopher B. Forsyth Christopher B. Forsyth Ali Keshavarzian Ali Keshavarzian Ali Keshavarzian Robin M. Voigt Robin M. Voigt Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
description	Alzheimer’s disease (AD) is a neurodegenerative disease that impacts 45 million people worldwide and is ranked as the 6th top cause of death among all adults by the Centers for Disease Control and Prevention. While genetics is an important risk factor for the development of AD, environment and lifestyle are also contributing risk factors. One such environmental factor is diet, which has emerged as a key influencer of AD development/progression as well as cognition. Diets containing large quantities of saturated/trans-fats, refined carbohydrates, limited intake of fiber, and alcohol are associated with cognitive dysfunction while conversely diets low in saturated/trans-fats (i.e., bad fats), high mono/polyunsaturated fats (i.e., good fats), high in fiber and polyphenols are associated with better cognitive function and memory in both humans and animal models. Mechanistically, this could be the direct consequence of dietary components (lipids, vitamins, polyphenols) on the brain, but other mechanisms are also likely to be important. Diet is considered to be the single greatest factor influencing the intestinal microbiome. Diet robustly influences the types and function of micro-organisms (called microbiota) that reside in the gastrointestinal tract. Availability of different types of nutrients (from the diet) will favor or disfavor the abundance and function of certain groups of microbiota. Microbiota are highly metabolically active and produce many metabolites and other factors that can affect the brain including cognition and the development and clinical progression of AD. This review summarizes data to support a model in which microbiota metabolites influence brain function and AD.
format	article
author	Dulce M. Frausto Christopher B. Forsyth Christopher B. Forsyth Ali Keshavarzian Ali Keshavarzian Ali Keshavarzian Robin M. Voigt Robin M. Voigt
author_facet	Dulce M. Frausto Christopher B. Forsyth Christopher B. Forsyth Ali Keshavarzian Ali Keshavarzian Ali Keshavarzian Robin M. Voigt Robin M. Voigt
author_sort	Dulce M. Frausto
title	Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
title_short	Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
title_full	Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
title_fullStr	Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
title_full_unstemmed	Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
title_sort	dietary regulation of gut-brain axis in alzheimer’s disease: importance of microbiota metabolites
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b623d3e1db7743b58fb94d88f94bfe83
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Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites

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