Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae

Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.

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Detalles Bibliográficos
Autores principales: Kevin C. Ma, Tatum D. Mortimer, Allison L. Hicks, Nicole E. Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel H. F. Rubin, Yi Wang, Deborah A. Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. Grad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
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Descripción
Sumario:Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.