Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.
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Nature Portfolio
2020
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oai:doaj.org-article:b6241a00f0f44ca29603bf59bca556102021-12-02T15:10:40ZAdaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae10.1038/s41467-020-17980-12041-1723https://doaj.org/article/b6241a00f0f44ca29603bf59bca556102020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17980-1https://doaj.org/toc/2041-1723Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.Kevin C. MaTatum D. MortimerAllison L. HicksNicole E. WheelerLeonor Sánchez-BusóDaniel GolparianGeorge TaiaroaDaniel H. F. RubinYi WangDeborah A. WilliamsonMagnus UnemoSimon R. HarrisYonatan H. GradNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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DOAJ |
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EN |
topic |
Science Q |
spellingShingle |
Science Q Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
description |
Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps. |
format |
article |
author |
Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad |
author_facet |
Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad |
author_sort |
Kevin C. Ma |
title |
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
title_short |
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
title_full |
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
title_fullStr |
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
title_full_unstemmed |
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae |
title_sort |
adaptation to the cervical environment is associated with increased antibiotic susceptibility in neisseria gonorrhoeae |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610 |
work_keys_str_mv |
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