Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae

Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.

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Autores principales: Kevin C. Ma, Tatum D. Mortimer, Allison L. Hicks, Nicole E. Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel H. F. Rubin, Yi Wang, Deborah A. Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. Grad
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
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spelling oai:doaj.org-article:b6241a00f0f44ca29603bf59bca556102021-12-02T15:10:40ZAdaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae10.1038/s41467-020-17980-12041-1723https://doaj.org/article/b6241a00f0f44ca29603bf59bca556102020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17980-1https://doaj.org/toc/2041-1723Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.Kevin C. MaTatum D. MortimerAllison L. HicksNicole E. WheelerLeonor Sánchez-BusóDaniel GolparianGeorge TaiaroaDaniel H. F. RubinYi WangDeborah A. WilliamsonMagnus UnemoSimon R. HarrisYonatan H. GradNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kevin C. Ma
Tatum D. Mortimer
Allison L. Hicks
Nicole E. Wheeler
Leonor Sánchez-Busó
Daniel Golparian
George Taiaroa
Daniel H. F. Rubin
Yi Wang
Deborah A. Williamson
Magnus Unemo
Simon R. Harris
Yonatan H. Grad
Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
description Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.
format article
author Kevin C. Ma
Tatum D. Mortimer
Allison L. Hicks
Nicole E. Wheeler
Leonor Sánchez-Busó
Daniel Golparian
George Taiaroa
Daniel H. F. Rubin
Yi Wang
Deborah A. Williamson
Magnus Unemo
Simon R. Harris
Yonatan H. Grad
author_facet Kevin C. Ma
Tatum D. Mortimer
Allison L. Hicks
Nicole E. Wheeler
Leonor Sánchez-Busó
Daniel Golparian
George Taiaroa
Daniel H. F. Rubin
Yi Wang
Deborah A. Williamson
Magnus Unemo
Simon R. Harris
Yonatan H. Grad
author_sort Kevin C. Ma
title Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_short Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_full Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_fullStr Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_full_unstemmed Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_sort adaptation to the cervical environment is associated with increased antibiotic susceptibility in neisseria gonorrhoeae
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
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