Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae

Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.

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Autores principales:	Kevin C. Ma, Tatum D. Mortimer, Allison L. Hicks, Nicole E. Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel H. F. Rubin, Yi Wang, Deborah A. Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. Grad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
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spelling	oai:doaj.org-article:b6241a00f0f44ca29603bf59bca556102021-12-02T15:10:40ZAdaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae10.1038/s41467-020-17980-12041-1723https://doaj.org/article/b6241a00f0f44ca29603bf59bca556102020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17980-1https://doaj.org/toc/2041-1723Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.Kevin C. MaTatum D. MortimerAllison L. HicksNicole E. WheelerLeonor Sánchez-BusóDaniel GolparianGeorge TaiaroaDaniel H. F. RubinYi WangDeborah A. WilliamsonMagnus UnemoSimon R. HarrisYonatan H. GradNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
description	Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.
format	article
author	Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad
author_facet	Kevin C. Ma Tatum D. Mortimer Allison L. Hicks Nicole E. Wheeler Leonor Sánchez-Busó Daniel Golparian George Taiaroa Daniel H. F. Rubin Yi Wang Deborah A. Williamson Magnus Unemo Simon R. Harris Yonatan H. Grad
author_sort	Kevin C. Ma
title	Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_short	Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_full	Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_fullStr	Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_full_unstemmed	Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae
title_sort	adaptation to the cervical environment is associated with increased antibiotic susceptibility in neisseria gonorrhoeae
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6241a00f0f44ca29603bf59bca55610
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Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae

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