The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.

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Autores principales:	Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu, Pumin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6255a7494034e8ba37a58fd202bf3a6
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spelling	oai:doaj.org-article:b6255a7494034e8ba37a58fd202bf3a62021-12-02T15:38:49ZThe anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites10.1038/ncomms157512041-1723https://doaj.org/article/b6255a7494034e8ba37a58fd202bf3a62017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15751https://doaj.org/toc/2041-1723The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.Kyungsoo HaChengxian MaHan LinLichun TangZhusheng LianFang ZhaoJu-Mei LiBei ZhenHuadong PeiSuxia HanMarcos MalumbresJianping JinHuan ChenYongxiang ZhaoQing ZhuPumin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyungsoo Ha Chengxian Ma Han Lin Lichun Tang Zhusheng Lian Fang Zhao Ju-Mei Li Bei Zhen Huadong Pei Suxia Han Marcos Malumbres Jianping Jin Huan Chen Yongxiang Zhao Qing Zhu Pumin Zhang The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
description	The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
format	article
author	Kyungsoo Ha Chengxian Ma Han Lin Lichun Tang Zhusheng Lian Fang Zhao Ju-Mei Li Bei Zhen Huadong Pei Suxia Han Marcos Malumbres Jianping Jin Huan Chen Yongxiang Zhao Qing Zhu Pumin Zhang
author_facet	Kyungsoo Ha Chengxian Ma Han Lin Lichun Tang Zhusheng Lian Fang Zhao Ju-Mei Li Bei Zhen Huadong Pei Suxia Han Marcos Malumbres Jianping Jin Huan Chen Yongxiang Zhao Qing Zhu Pumin Zhang
author_sort	Kyungsoo Ha
title	The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
title_short	The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
title_full	The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
title_fullStr	The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
title_full_unstemmed	The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
title_sort	anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at dna damage sites
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b6255a7494034e8ba37a58fd202bf3a6
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The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

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