Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters

ABSTRACT Viral diseases cause significant losses in aquaculture. Prophylactic measures, such as immune priming, are promising control strategies. Treatment of the Pacific oyster (Crassostrea gigas) with the double-stranded RNA analog poly(I·C) confers long-term protection against infection with ostr...

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Autor principal:	Nelson E. Martins
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	ostreid herpesvirus interferons invertebrate-microbe interactions mollusks Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b6263c67039f4d1a8b233f7316c20836
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spelling	oai:doaj.org-article:b6263c67039f4d1a8b233f7316c208362021-11-15T15:57:03ZTowards a Mechanism for Poly(I·C) Antiviral Priming in Oysters10.1128/mBio.00407-202150-7511https://doaj.org/article/b6263c67039f4d1a8b233f7316c208362020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00407-20https://doaj.org/toc/2150-7511ABSTRACT Viral diseases cause significant losses in aquaculture. Prophylactic measures, such as immune priming, are promising control strategies. Treatment of the Pacific oyster (Crassostrea gigas) with the double-stranded RNA analog poly(I·C) confers long-term protection against infection with ostreid herpesvirus 1, the causative agent of Pacific oyster mortality syndrome. In a recent article in mBio, Lafont and coauthors (M. Lafont, A. Vergnes, J. Vidal-Dupiol, J. de Lorgeril, et al., mBio 11:e02777-19, 2020, https://doi.org/10.1128/mBio.02777-19) characterized the transcriptome of oysters treated with poly(I·C). This immune stimulator induced genes related to the interferon and apoptosis pathways. This response overlaps the response to viral infection, and high expression levels of potential effector genes are maintained for up to 4 months. This work opens the door to characterization of the phenomena of immune priming in a poorly studied invertebrate model. It also highlights the importance of interferon-like responses for invertebrate antiviral immunity.Nelson E. MartinsAmerican Society for Microbiologyarticleostreid herpesvirusinterferonsinvertebrate-microbe interactionsmollusksMicrobiologyQR1-502ENmBio, Vol 11, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ostreid herpesvirus interferons invertebrate-microbe interactions mollusks Microbiology QR1-502
spellingShingle	ostreid herpesvirus interferons invertebrate-microbe interactions mollusks Microbiology QR1-502 Nelson E. Martins Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
description	ABSTRACT Viral diseases cause significant losses in aquaculture. Prophylactic measures, such as immune priming, are promising control strategies. Treatment of the Pacific oyster (Crassostrea gigas) with the double-stranded RNA analog poly(I·C) confers long-term protection against infection with ostreid herpesvirus 1, the causative agent of Pacific oyster mortality syndrome. In a recent article in mBio, Lafont and coauthors (M. Lafont, A. Vergnes, J. Vidal-Dupiol, J. de Lorgeril, et al., mBio 11:e02777-19, 2020, https://doi.org/10.1128/mBio.02777-19) characterized the transcriptome of oysters treated with poly(I·C). This immune stimulator induced genes related to the interferon and apoptosis pathways. This response overlaps the response to viral infection, and high expression levels of potential effector genes are maintained for up to 4 months. This work opens the door to characterization of the phenomena of immune priming in a poorly studied invertebrate model. It also highlights the importance of interferon-like responses for invertebrate antiviral immunity.
format	article
author	Nelson E. Martins
author_facet	Nelson E. Martins
author_sort	Nelson E. Martins
title	Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
title_short	Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
title_full	Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
title_fullStr	Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
title_full_unstemmed	Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
title_sort	towards a mechanism for poly(i·c) antiviral priming in oysters
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/b6263c67039f4d1a8b233f7316c20836
work_keys_str_mv	AT nelsonemartins towardsamechanismforpolyicantiviralpriminginoysters
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Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters

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