The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse

Dubravka Svob Strac,1 Gordana Nedic Erjavec,1 Matea Nikolac Perkovic,1 Korona Nenadic-Sviglin,2 Marcela Konjevod,1 Mirko Grubor,3 Nela Pivac1 1Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia; 2Center for Alcoholism and other Addic...

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Autores principales:	Svob Strac D, Nedic Erjavec G, Nikolac Perkovic M, Nenadic-Sviglin K, Konjevod M, Grubor M, Pivac N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	alcoholism age of onset HTR1B gene variants platelet serotonin smoking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b62b81cf155d4de690c27c627b55f911
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spelling	oai:doaj.org-article:b62b81cf155d4de690c27c627b55f9112021-12-02T01:39:45ZThe association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse1178-2021https://doaj.org/article/b62b81cf155d4de690c27c627b55f9112019-01-01T00:00:00Zhttps://www.dovepress.com/the-association-between-htr1b-gene-rs13212041-polymorphism-and-onset-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dubravka Svob Strac,1 Gordana Nedic Erjavec,1 Matea Nikolac Perkovic,1 Korona Nenadic-Sviglin,2 Marcela Konjevod,1 Mirko Grubor,3 Nela Pivac1 1Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia; 2Center for Alcoholism and other Addictions, University Psychiatric Hospital Vrapce, Zagreb, Croatia; 3Faculty of Pharmacy and Biochemistry University of Zagreb, Zagreb, Croatia Background: Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission. The rs13212041 polymorphism modulates the expression of HTR1B gene coding for 5-HT1B receptor. This study examined the association of platelet serotonin (5-HT) and HTR1B gene with the onset of alcohol abuse in alcohol-dependent subjects. Materials and methods: Determination of platelet 5-HT concentration and genotyping of rs13212041 HTR1B gene polymorphism were performed in 613 alcohol-dependent patients, subdivided according to early/late onset (before/after 25 years of age) of alcohol abuse. Results: Alcohol-dependent individuals with CC genotype were more frequent in the group with early onset of alcohol abuse compared to carriers of T allele. Besides HTR1B genotype, age and gender, but not platelet 5-HT, were major variables associated with the onset of alcohol abuse. Platelet 5-HT concentration was not significantly different between patients with early and late onset of alcohol abuse, or patients carrying various HTR1B genotypes. Although we observed no influence of co-variables such as age, gender, or somatic and psychiatric comorbidities, platelet 5-HT concentration was significantly affected by smoking. Conclusion: These findings support potential involvement of 5-HT1B receptors in the onset of alcohol abuse and development of alcohol dependence. Additionally, the results of our study emphasize the importance of controlling for smoking status, as one of the significant confounding factors influencing platelet 5-HT concentration. Keywords: alcoholism, age of onset, 5-HT1B, gene variants, platelet serotonin, smokingSvob Strac DNedic Erjavec GNikolac Perkovic MNenadic-Sviglin KKonjevod MGrubor MPivac NDove Medical Pressarticlealcoholismage of onsetHTR1B gene variantsplatelet serotoninsmokingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 339-347 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	alcoholism age of onset HTR1B gene variants platelet serotonin smoking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	alcoholism age of onset HTR1B gene variants platelet serotonin smoking Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Svob Strac D Nedic Erjavec G Nikolac Perkovic M Nenadic-Sviglin K Konjevod M Grubor M Pivac N The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
description	Dubravka Svob Strac,1 Gordana Nedic Erjavec,1 Matea Nikolac Perkovic,1 Korona Nenadic-Sviglin,2 Marcela Konjevod,1 Mirko Grubor,3 Nela Pivac1 1Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia; 2Center for Alcoholism and other Addictions, University Psychiatric Hospital Vrapce, Zagreb, Croatia; 3Faculty of Pharmacy and Biochemistry University of Zagreb, Zagreb, Croatia Background: Alcohol dependence displays a wide variety of clinical phenotypes. Various typology classifications of alcoholism include age of onset of alcohol abuse as one of the major phenotypic features. Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission. The rs13212041 polymorphism modulates the expression of HTR1B gene coding for 5-HT1B receptor. This study examined the association of platelet serotonin (5-HT) and HTR1B gene with the onset of alcohol abuse in alcohol-dependent subjects. Materials and methods: Determination of platelet 5-HT concentration and genotyping of rs13212041 HTR1B gene polymorphism were performed in 613 alcohol-dependent patients, subdivided according to early/late onset (before/after 25 years of age) of alcohol abuse. Results: Alcohol-dependent individuals with CC genotype were more frequent in the group with early onset of alcohol abuse compared to carriers of T allele. Besides HTR1B genotype, age and gender, but not platelet 5-HT, were major variables associated with the onset of alcohol abuse. Platelet 5-HT concentration was not significantly different between patients with early and late onset of alcohol abuse, or patients carrying various HTR1B genotypes. Although we observed no influence of co-variables such as age, gender, or somatic and psychiatric comorbidities, platelet 5-HT concentration was significantly affected by smoking. Conclusion: These findings support potential involvement of 5-HT1B receptors in the onset of alcohol abuse and development of alcohol dependence. Additionally, the results of our study emphasize the importance of controlling for smoking status, as one of the significant confounding factors influencing platelet 5-HT concentration. Keywords: alcoholism, age of onset, 5-HT1B, gene variants, platelet serotonin, smoking
format	article
author	Svob Strac D Nedic Erjavec G Nikolac Perkovic M Nenadic-Sviglin K Konjevod M Grubor M Pivac N
author_facet	Svob Strac D Nedic Erjavec G Nikolac Perkovic M Nenadic-Sviglin K Konjevod M Grubor M Pivac N
author_sort	Svob Strac D
title	The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
title_short	The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
title_full	The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
title_fullStr	The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
title_full_unstemmed	The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse
title_sort	association between htr1b gene rs13212041 polymorphism and onset of alcohol abuse
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b62b81cf155d4de690c27c627b55f911
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The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse

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