Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension

Abstract Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic...

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Autores principales:	Noriyuki Enomoto, Seiichiro Suzuki, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Yutaro Nakamura, Keiichi Odagiri, Takamichi Ishikawa, Kensuke Kataoka, Yasuhiro Kondoh, Masato Maekawa, Naoki Inui, Hiroshi Watanabe, Takafumi Suda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b62c1458ba874883abda9d955c71b632
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spelling	oai:doaj.org-article:b62c1458ba874883abda9d955c71b6322021-12-02T18:46:53ZDiagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension10.1038/s41598-021-94907-w2045-2322https://doaj.org/article/b62c1458ba874883abda9d955c71b6322021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94907-whttps://doaj.org/toc/2045-2322Abstract Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p < 0.001), right ventricular diameter on echocardiography (r = 0.565, p = 0.035), and mean pulmonary arterial pressure (r = 0.449, p = 0.032) and pulmonary vascular resistance (r = 0.451, p = 0.031) on right-heart catheterization. ANGP-1 and ANGP-2 were expressed on lung vascular endothelial cells, as shown by immunohistochemistry. Patients with PH with higher ANGP-2 concentration (≥ 2.48 ng/mL) had significantly worse survival (p = 0.022). Higher ANGP-2 concentration was a significant worse prognostic factor (hazard ratio = 6.063, p = 0.037), while serum ANGP-1 concentration was not. In conclusion, serum ANGP-2 may be a useful diagnostic and prognostic biomarker in patients with PH, especially in patients with group 3 PH.Noriyuki EnomotoSeiichiro SuzukiHironao HozumiMasato KarayamaYuzo SuzukiKazuki FuruhashiTomoyuki FujisawaYutaro NakamuraKeiichi OdagiriTakamichi IshikawaKensuke KataokaYasuhiro KondohMasato MaekawaNaoki InuiHiroshi WatanabeTakafumi SudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noriyuki Enomoto Seiichiro Suzuki Hironao Hozumi Masato Karayama Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Keiichi Odagiri Takamichi Ishikawa Kensuke Kataoka Yasuhiro Kondoh Masato Maekawa Naoki Inui Hiroshi Watanabe Takafumi Suda Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
description	Abstract Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p < 0.001), right ventricular diameter on echocardiography (r = 0.565, p = 0.035), and mean pulmonary arterial pressure (r = 0.449, p = 0.032) and pulmonary vascular resistance (r = 0.451, p = 0.031) on right-heart catheterization. ANGP-1 and ANGP-2 were expressed on lung vascular endothelial cells, as shown by immunohistochemistry. Patients with PH with higher ANGP-2 concentration (≥ 2.48 ng/mL) had significantly worse survival (p = 0.022). Higher ANGP-2 concentration was a significant worse prognostic factor (hazard ratio = 6.063, p = 0.037), while serum ANGP-1 concentration was not. In conclusion, serum ANGP-2 may be a useful diagnostic and prognostic biomarker in patients with PH, especially in patients with group 3 PH.
format	article
author	Noriyuki Enomoto Seiichiro Suzuki Hironao Hozumi Masato Karayama Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Keiichi Odagiri Takamichi Ishikawa Kensuke Kataoka Yasuhiro Kondoh Masato Maekawa Naoki Inui Hiroshi Watanabe Takafumi Suda
author_facet	Noriyuki Enomoto Seiichiro Suzuki Hironao Hozumi Masato Karayama Yuzo Suzuki Kazuki Furuhashi Tomoyuki Fujisawa Yutaro Nakamura Keiichi Odagiri Takamichi Ishikawa Kensuke Kataoka Yasuhiro Kondoh Masato Maekawa Naoki Inui Hiroshi Watanabe Takafumi Suda
author_sort	Noriyuki Enomoto
title	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
title_short	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
title_full	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
title_fullStr	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
title_full_unstemmed	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
title_sort	diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b62c1458ba874883abda9d955c71b632
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Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension

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