Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.

<h4>Purpose</h4>To compare the risk of neurodevelopmental disorders in children conceived via intracytoplasmic sperm injection (ICSI) and those conceived naturally.<h4>Materials and methods</h4>A population-based cohort study using data retrieved from the Taipei Medical Unive...

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Autores principales:	Cheng-Wei Wang, Tzu-Hao Chang, Nai-Chen Chuang, Heng-Kien Au, Chi-Huang Chen, Sung-Hui Tseng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b62fb4dafa68416d9131a1ad0642f3cb
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spelling	oai:doaj.org-article:b62fb4dafa68416d9131a1ad0642f3cb2021-12-02T20:14:41ZAssociation between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.1932-620310.1371/journal.pone.0257268https://doaj.org/article/b62fb4dafa68416d9131a1ad0642f3cb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257268https://doaj.org/toc/1932-6203<h4>Purpose</h4>To compare the risk of neurodevelopmental disorders in children conceived via intracytoplasmic sperm injection (ICSI) and those conceived naturally.<h4>Materials and methods</h4>A population-based cohort study using data retrieved from the Taipei Medical University Research Database (TMURD) from January, 2004 to August, 2016. The data included maternal pregnancy history, perinatal history and developmental follow up of their babies up to 5 years of age. The study included 23885 children, of whom 23148 were naturally conceived and 737 were conceived via ICSI. Neurodevelopmental disorders defined by 21 ICD-9-CM codes.<h4>Results</h4>Of the 23885 children enrolled for analysis, 2778 children were included for further subgrouping analysis after propensity matching to reduce bias from maternal factors. The single-birth group included 1752 naturally conceived (NC) children and 438 ICSI children. The multiple-birth group included 294 NC and 294 ICSI children. The risk of neurodevelopmental disorders was not increased for ICSI children in both groups (single birth: adjusted hazard ratio aHR = 0.70, 95% CI = 0.39-1.27, p = 0.243; multiple-birth group aHR = 0.77, 95% CI = 0.43-1.35, p = 0.853). In the single-birth group, multivariate analyses showed that male sex (aHR = 1.81, 95% CI = 1.29-2.54, p < 0.001), and intensive care unit (ICU) admission (aHR = 3.10, 95% CI = 1.64-5.86, p < 0.001) were risk factors for neurodevelopmental disorders. In the multiple-birth group, multivariate analyses demonstrated that ICU admission (aHR = 3.58, 95% CI = 1.82-7.04, p < 0.001), was risk factor for neurodevelopmental disorders.<h4>Conclusion</h4>Our study indicated that the use of ICSI does not associated with higher risk of neurodevelopmental disorders in the offspring. But male sex, and ICU admission do have increased risk of neurodevelopmental disorders. However, long term follow up of this cohort on health outcomes in adolescence and adulthood will strengthen the conclusions that ICSI is safe regarding offspring long term outcome.Cheng-Wei WangTzu-Hao ChangNai-Chen ChuangHeng-Kien AuChi-Huang ChenSung-Hui TsengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257268 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng-Wei Wang Tzu-Hao Chang Nai-Chen Chuang Heng-Kien Au Chi-Huang Chen Sung-Hui Tseng Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
description	<h4>Purpose</h4>To compare the risk of neurodevelopmental disorders in children conceived via intracytoplasmic sperm injection (ICSI) and those conceived naturally.<h4>Materials and methods</h4>A population-based cohort study using data retrieved from the Taipei Medical University Research Database (TMURD) from January, 2004 to August, 2016. The data included maternal pregnancy history, perinatal history and developmental follow up of their babies up to 5 years of age. The study included 23885 children, of whom 23148 were naturally conceived and 737 were conceived via ICSI. Neurodevelopmental disorders defined by 21 ICD-9-CM codes.<h4>Results</h4>Of the 23885 children enrolled for analysis, 2778 children were included for further subgrouping analysis after propensity matching to reduce bias from maternal factors. The single-birth group included 1752 naturally conceived (NC) children and 438 ICSI children. The multiple-birth group included 294 NC and 294 ICSI children. The risk of neurodevelopmental disorders was not increased for ICSI children in both groups (single birth: adjusted hazard ratio aHR = 0.70, 95% CI = 0.39-1.27, p = 0.243; multiple-birth group aHR = 0.77, 95% CI = 0.43-1.35, p = 0.853). In the single-birth group, multivariate analyses showed that male sex (aHR = 1.81, 95% CI = 1.29-2.54, p < 0.001), and intensive care unit (ICU) admission (aHR = 3.10, 95% CI = 1.64-5.86, p < 0.001) were risk factors for neurodevelopmental disorders. In the multiple-birth group, multivariate analyses demonstrated that ICU admission (aHR = 3.58, 95% CI = 1.82-7.04, p < 0.001), was risk factor for neurodevelopmental disorders.<h4>Conclusion</h4>Our study indicated that the use of ICSI does not associated with higher risk of neurodevelopmental disorders in the offspring. But male sex, and ICU admission do have increased risk of neurodevelopmental disorders. However, long term follow up of this cohort on health outcomes in adolescence and adulthood will strengthen the conclusions that ICSI is safe regarding offspring long term outcome.
format	article
author	Cheng-Wei Wang Tzu-Hao Chang Nai-Chen Chuang Heng-Kien Au Chi-Huang Chen Sung-Hui Tseng
author_facet	Cheng-Wei Wang Tzu-Hao Chang Nai-Chen Chuang Heng-Kien Au Chi-Huang Chen Sung-Hui Tseng
author_sort	Cheng-Wei Wang
title	Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
title_short	Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
title_full	Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
title_fullStr	Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
title_full_unstemmed	Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
title_sort	association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b62fb4dafa68416d9131a1ad0642f3cb
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_version_	1718374667046092800

Association between intracytoplasmic sperm injection and neurodevelopmental outcomes among offspring.

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