Gαq activation modulates autophagy by promoting mTORC1 signaling

Gαq activation modulates autophagy by promoting mTORC1 signaling

Nutrient status in the cell regulates autophagy via mTORC1 activity. Here, the authors show that the ubiquitous G protein subunit Gαq contributes to nutrient sensing by promoting formation of an mTOR-p62-Raptor complex in replete conditions, modulating autophagy.

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Autores principales: Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor, Catalina Ribas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b633204dd82c4a36a9216ada8eca36a2
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spelling oai:doaj.org-article:b633204dd82c4a36a9216ada8eca36a22021-12-02T16:31:49ZGαq activation modulates autophagy by promoting mTORC1 signaling10.1038/s41467-021-24811-42041-1723https://doaj.org/article/b633204dd82c4a36a9216ada8eca36a22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24811-4https://doaj.org/toc/2041-1723Nutrient status in the cell regulates autophagy via mTORC1 activity. Here, the authors show that the ubiquitous G protein subunit Gαq contributes to nutrient sensing by promoting formation of an mTOR-p62-Raptor complex in replete conditions, modulating autophagy.Sofía CabezudoMaria Sanz-FloresAlvaro CaballeroInmaculada TassetElena RebolloAntonio DiazAnna M. AragayAna María CuervoFederico MayorCatalina RibasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sofía Cabezudo
Maria Sanz-Flores
Alvaro Caballero
Inmaculada Tasset
Elena Rebollo
Antonio Diaz
Anna M. Aragay
Ana María Cuervo
Federico Mayor
Catalina Ribas
Gαq activation modulates autophagy by promoting mTORC1 signaling
description Nutrient status in the cell regulates autophagy via mTORC1 activity. Here, the authors show that the ubiquitous G protein subunit Gαq contributes to nutrient sensing by promoting formation of an mTOR-p62-Raptor complex in replete conditions, modulating autophagy.
format article
author Sofía Cabezudo
Maria Sanz-Flores
Alvaro Caballero
Inmaculada Tasset
Elena Rebollo
Antonio Diaz
Anna M. Aragay
Ana María Cuervo
Federico Mayor
Catalina Ribas
author_facet Sofía Cabezudo
Maria Sanz-Flores
Alvaro Caballero
Inmaculada Tasset
Elena Rebollo
Antonio Diaz
Anna M. Aragay
Ana María Cuervo
Federico Mayor
Catalina Ribas
author_sort Sofía Cabezudo
title Gαq activation modulates autophagy by promoting mTORC1 signaling
title_short Gαq activation modulates autophagy by promoting mTORC1 signaling
title_full Gαq activation modulates autophagy by promoting mTORC1 signaling
title_fullStr Gαq activation modulates autophagy by promoting mTORC1 signaling
title_full_unstemmed Gαq activation modulates autophagy by promoting mTORC1 signaling
title_sort gαq activation modulates autophagy by promoting mtorc1 signaling
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b633204dd82c4a36a9216ada8eca36a2
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