Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery

Rekha Khandelwal,1 Madhavi Bijlani,1 Dhananjay Raje,2 Anand Rathi11Department of Ophthalmology, NKP Salve Institute of Medical Sciences & Lata Mangeshkar Hospital, Nagpur 440019, India; 2MDS Bio Analytics, Nagpur 440010, IndiaPurpose: To compare the efficacy of 0.2 mg/ml Mitomycin C (MMC) ap...

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Autores principales:	Khandelwal R, Bijlani M, Raje D, Rathi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Key words : Glaucoma combined surgery Mitomycin C trabeculectomy safe surgery system trabeculectomy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b634ceef63b34202b0c4407b9c5782cf
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spelling	oai:doaj.org-article:b634ceef63b34202b0c4407b9c5782cf2021-12-02T06:45:46ZEvaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery1177-5483https://doaj.org/article/b634ceef63b34202b0c4407b9c5782cf2019-05-01T00:00:00Zhttps://www.dovepress.com/evaluating-the-efficacy-of-short-duration-mitomycin-c-in-safe-surgery--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Rekha Khandelwal,1 Madhavi Bijlani,1 Dhananjay Raje,2 Anand Rathi11Department of Ophthalmology, NKP Salve Institute of Medical Sciences & Lata Mangeshkar Hospital, Nagpur 440019, India; 2MDS Bio Analytics, Nagpur 440010, IndiaPurpose: To compare the efficacy of 0.2 mg/ml Mitomycin C (MMC) applied for 1-minute versus 2-minutes in patients undergoing combined surgery for primary glaucoma coexistent with cataract.Materials and methods: This was a randomized controlled clinical trial of 63 patients operated on for primary glaucoma (POAG or PACG) with visually significant cataract. All patients underwent safe surgery system trabeculectomy with manual small incision cataract surgery (MSIC) and implantation of PC IOL. Patients were randomized into intra-operative MMC 0.2 mg/ml for 1-minute (study group) and MMC 0.2 mg/ml for 2-minutes (control group). Success was measured on the basis of two different intraocular pressure (IOP) goals (IOP ≤21 mmHg, IOP ≤18 mmHg) and mean IOP reduction from baseline at the end of 12 months.Results: At 12 months, significant decreases in mean IOP were observed in both groups (P<0.001).The mean IOP reduction was 31.33±9.06% in the study group, as compared to 43.32±9.38% in the control group (P<0.001). The overall success for IOP ≤21 mm Hg was 80.5% in the study group and 90.9% in the control group (P<0.05). Kaplan-Meier analysis showed an insignificant difference in overall success rates of the two groups.Conclusion: The IOP reduction with 2-minute MMC (0.2 mg/ml) is more effective than 1-minute MMC after 12 months. It offers a decrease in anti-glaucoma medications and substantial visual recovery in combined surgery done for primary glaucoma coexistent with cataract.Keywords: glaucoma, combined surgery, Mitomycin C, trabeculectomy, safe surgery system trabeculectomyKhandelwal RBijlani MRaje DRathi ADove Medical PressarticleKey words : Glaucomacombined surgeryMitomycin Ctrabeculectomysafe surgery system trabeculectomyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 849-857 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Key words : Glaucoma combined surgery Mitomycin C trabeculectomy safe surgery system trabeculectomy Ophthalmology RE1-994
spellingShingle	Key words : Glaucoma combined surgery Mitomycin C trabeculectomy safe surgery system trabeculectomy Ophthalmology RE1-994 Khandelwal R Bijlani M Raje D Rathi A Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
description	Rekha Khandelwal,1 Madhavi Bijlani,1 Dhananjay Raje,2 Anand Rathi11Department of Ophthalmology, NKP Salve Institute of Medical Sciences & Lata Mangeshkar Hospital, Nagpur 440019, India; 2MDS Bio Analytics, Nagpur 440010, IndiaPurpose: To compare the efficacy of 0.2 mg/ml Mitomycin C (MMC) applied for 1-minute versus 2-minutes in patients undergoing combined surgery for primary glaucoma coexistent with cataract.Materials and methods: This was a randomized controlled clinical trial of 63 patients operated on for primary glaucoma (POAG or PACG) with visually significant cataract. All patients underwent safe surgery system trabeculectomy with manual small incision cataract surgery (MSIC) and implantation of PC IOL. Patients were randomized into intra-operative MMC 0.2 mg/ml for 1-minute (study group) and MMC 0.2 mg/ml for 2-minutes (control group). Success was measured on the basis of two different intraocular pressure (IOP) goals (IOP ≤21 mmHg, IOP ≤18 mmHg) and mean IOP reduction from baseline at the end of 12 months.Results: At 12 months, significant decreases in mean IOP were observed in both groups (P<0.001).The mean IOP reduction was 31.33±9.06% in the study group, as compared to 43.32±9.38% in the control group (P<0.001). The overall success for IOP ≤21 mm Hg was 80.5% in the study group and 90.9% in the control group (P<0.05). Kaplan-Meier analysis showed an insignificant difference in overall success rates of the two groups.Conclusion: The IOP reduction with 2-minute MMC (0.2 mg/ml) is more effective than 1-minute MMC after 12 months. It offers a decrease in anti-glaucoma medications and substantial visual recovery in combined surgery done for primary glaucoma coexistent with cataract.Keywords: glaucoma, combined surgery, Mitomycin C, trabeculectomy, safe surgery system trabeculectomy
format	article
author	Khandelwal R Bijlani M Raje D Rathi A
author_facet	Khandelwal R Bijlani M Raje D Rathi A
author_sort	Khandelwal R
title	Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
title_short	Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
title_full	Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
title_fullStr	Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
title_full_unstemmed	Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery
title_sort	evaluating the efficacy of short duration mitomycin c in safe surgery system trabeculectomy combined with cataract surgery
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/b634ceef63b34202b0c4407b9c5782cf
work_keys_str_mv	AT khandelwalr evaluatingtheefficacyofshortdurationmitomycincinsafesurgerysystemtrabeculectomycombinedwithcataractsurgery AT bijlanim evaluatingtheefficacyofshortdurationmitomycincinsafesurgerysystemtrabeculectomycombinedwithcataractsurgery AT rajed evaluatingtheefficacyofshortdurationmitomycincinsafesurgerysystemtrabeculectomycombinedwithcataractsurgery AT rathia evaluatingtheefficacyofshortdurationmitomycincinsafesurgerysystemtrabeculectomycombinedwithcataractsurgery
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Evaluating the efficacy of short duration Mitomycin C in safe surgery system trabeculectomy combined with cataract surgery

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