Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma

Cellular senescence plays a crucial role in tumorigenesis, development and immune modulation in cancers. However, to date, a robust and reliable cellular senescence-related signature and its value in clinical outcomes and immunotherapy response remain unexplored in lung adenocarcinoma (LUAD) patient...

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Autores principales:	Weihao Lin, Xin Wang, Zhen Wang, Fei Shao, Yannan Yang, Zheng Cao, Xiaoli Feng, Yibo Gao, Jie He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lung adenocarcinoma cellular senescence senescence-associated secretory phenotype tumor microenvironment prognosis immunotherapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b6371768b2ec43edbdc17fac425ad0f4
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spelling	oai:doaj.org-article:b6371768b2ec43edbdc17fac425ad0f42021-11-16T05:18:04ZComprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma2296-634X10.3389/fcell.2021.780461https://doaj.org/article/b6371768b2ec43edbdc17fac425ad0f42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780461/fullhttps://doaj.org/toc/2296-634XCellular senescence plays a crucial role in tumorigenesis, development and immune modulation in cancers. However, to date, a robust and reliable cellular senescence-related signature and its value in clinical outcomes and immunotherapy response remain unexplored in lung adenocarcinoma (LUAD) patients. Through exploring the expression profiles of 278 cellular senescence-related genes in 936 LUAD patients, a cellular senescence-related signature (SRS) was constructed and validated as an independent prognostic predictor for LUAD patients. Notably, patients with high SRS scores exhibited upregulation of senescence-associated secretory phenotype (SASP) and an immunosuppressive phenotype. Further analysis showed that SRS combined with immune checkpoint expression or TMB served as a good predictor for patients’ clinical outcomes, and patients with low SRS scores might benefit from immunotherapy. Collectively, our findings demonstrated that SRS involved in the regulation of the tumor immune microenvironment through SASP was a robust biomarker for the immunotherapeutic response and prognosis in LUAD.Weihao LinXin WangZhen WangFei ShaoYannan YangZheng CaoXiaoli FengYibo GaoYibo GaoJie HeJie HeFrontiers Media S.A.articlelung adenocarcinomacellular senescencesenescence-associated secretory phenotypetumor microenvironmentprognosisimmunotherapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma cellular senescence senescence-associated secretory phenotype tumor microenvironment prognosis immunotherapy Biology (General) QH301-705.5
spellingShingle	lung adenocarcinoma cellular senescence senescence-associated secretory phenotype tumor microenvironment prognosis immunotherapy Biology (General) QH301-705.5 Weihao Lin Xin Wang Zhen Wang Fei Shao Yannan Yang Zheng Cao Xiaoli Feng Yibo Gao Yibo Gao Jie He Jie He Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
description	Cellular senescence plays a crucial role in tumorigenesis, development and immune modulation in cancers. However, to date, a robust and reliable cellular senescence-related signature and its value in clinical outcomes and immunotherapy response remain unexplored in lung adenocarcinoma (LUAD) patients. Through exploring the expression profiles of 278 cellular senescence-related genes in 936 LUAD patients, a cellular senescence-related signature (SRS) was constructed and validated as an independent prognostic predictor for LUAD patients. Notably, patients with high SRS scores exhibited upregulation of senescence-associated secretory phenotype (SASP) and an immunosuppressive phenotype. Further analysis showed that SRS combined with immune checkpoint expression or TMB served as a good predictor for patients’ clinical outcomes, and patients with low SRS scores might benefit from immunotherapy. Collectively, our findings demonstrated that SRS involved in the regulation of the tumor immune microenvironment through SASP was a robust biomarker for the immunotherapeutic response and prognosis in LUAD.
format	article
author	Weihao Lin Xin Wang Zhen Wang Fei Shao Yannan Yang Zheng Cao Xiaoli Feng Yibo Gao Yibo Gao Jie He Jie He
author_facet	Weihao Lin Xin Wang Zhen Wang Fei Shao Yannan Yang Zheng Cao Xiaoli Feng Yibo Gao Yibo Gao Jie He Jie He
author_sort	Weihao Lin
title	Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
title_short	Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
title_full	Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
title_fullStr	Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
title_full_unstemmed	Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
title_sort	comprehensive analysis uncovers prognostic and immunogenic characteristics of cellular senescence for lung adenocarcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b6371768b2ec43edbdc17fac425ad0f4
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Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma

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