Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization

The deficient functional polarization of macrophages is implicated in the disease progression of autoimmune hepatitis (AIH). This study aims to evaluate the impact of Magnesium isoglycyrrhizinate (MgIG) on concanavalin A (Con A)-induced hepatitis in a mouse model, thereby clarifying the molecular me...

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Autores principales:	Rui Lin, Yun Liu, Meiyu Piao, Yan Song
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	autoimmune hepatitis magnesium isoglycyrrhizinate concanavalin a macrophages Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b63929f1c7a24103a47b97cccee202e2
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spelling	oai:doaj.org-article:b63929f1c7a24103a47b97cccee202e22021-11-26T11:19:47ZMagnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization0954-01051465-344310.1080/09540105.2018.1508424https://doaj.org/article/b63929f1c7a24103a47b97cccee202e22018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1508424https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443The deficient functional polarization of macrophages is implicated in the disease progression of autoimmune hepatitis (AIH). This study aims to evaluate the impact of Magnesium isoglycyrrhizinate (MgIG) on concanavalin A (Con A)-induced hepatitis in a mouse model, thereby clarifying the molecular mechanisms with which it is associated. MgIG was periodically administered to C57BL/6 mice before one intravenous injection of Con A (20 mg/kg). The MgIG treatment demonstrated a protective function in mice for Con A-induced AIH, the expression of proinflammatory cytokines, and the serum levels of alanine aminotransferase and aspartate aminotransferase. In addition, the MgIG pre-treatment had a significant effect on the number of F4/80+ cells entering the liver. MgIG efficiently facilitated macrophage polarization toward an M2 phenotype. The results indicate that a relationship may exist between the protective impacts of MgIG with respect to Con A-induced liver injury and the capability of the hepatoprotective agent to regulate macrophage polarization.Rui LinYun LiuMeiyu PiaoYan SongTaylor & Francis Grouparticleautoimmune hepatitismagnesium isoglycyrrhizinateconcanavalin amacrophagesAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 1041-1052 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune hepatitis magnesium isoglycyrrhizinate concanavalin a macrophages Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmune hepatitis magnesium isoglycyrrhizinate concanavalin a macrophages Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Rui Lin Yun Liu Meiyu Piao Yan Song Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
description	The deficient functional polarization of macrophages is implicated in the disease progression of autoimmune hepatitis (AIH). This study aims to evaluate the impact of Magnesium isoglycyrrhizinate (MgIG) on concanavalin A (Con A)-induced hepatitis in a mouse model, thereby clarifying the molecular mechanisms with which it is associated. MgIG was periodically administered to C57BL/6 mice before one intravenous injection of Con A (20 mg/kg). The MgIG treatment demonstrated a protective function in mice for Con A-induced AIH, the expression of proinflammatory cytokines, and the serum levels of alanine aminotransferase and aspartate aminotransferase. In addition, the MgIG pre-treatment had a significant effect on the number of F4/80+ cells entering the liver. MgIG efficiently facilitated macrophage polarization toward an M2 phenotype. The results indicate that a relationship may exist between the protective impacts of MgIG with respect to Con A-induced liver injury and the capability of the hepatoprotective agent to regulate macrophage polarization.
format	article
author	Rui Lin Yun Liu Meiyu Piao Yan Song
author_facet	Rui Lin Yun Liu Meiyu Piao Yan Song
author_sort	Rui Lin
title	Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
title_short	Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
title_full	Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
title_fullStr	Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
title_full_unstemmed	Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization
title_sort	magnesium isoglycyrrhizinate positively affects concanavalin a-induced liver damage by regulating macrophage polarization
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/b63929f1c7a24103a47b97cccee202e2
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Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization

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