Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibitor (IDH305) in 8 mutant IDH1 glioma patients.

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Autores principales:	Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Wolfgang Bogner, Eva M. Ratai, Kara Reitz, A. John Iafrate, Jorg Dietrich, Elizabeth R. Gerstner, Andrew S. Chi, Bruce R. Rosen, Patrick Y. Wen, Daniel P. Cahill, Tracy T. Batchelor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6420b3093174f1f828f783b189caae2
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spelling	oai:doaj.org-article:b6420b3093174f1f828f783b189caae22021-12-02T15:34:23ZPharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate10.1038/s41467-018-03905-62041-1723https://doaj.org/article/b6420b3093174f1f828f783b189caae22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03905-6https://doaj.org/toc/2041-1723Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibitor (IDH305) in 8 mutant IDH1 glioma patients.Ovidiu C. AndronesiIsabel C. Arrillaga-RomanyK. Ina LyWolfgang BognerEva M. RataiKara ReitzA. John IafrateJorg DietrichElizabeth R. GerstnerAndrew S. ChiBruce R. RosenPatrick Y. WenDaniel P. CahillTracy T. BatchelorNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ovidiu C. Andronesi Isabel C. Arrillaga-Romany K. Ina Ly Wolfgang Bogner Eva M. Ratai Kara Reitz A. John Iafrate Jorg Dietrich Elizabeth R. Gerstner Andrew S. Chi Bruce R. Rosen Patrick Y. Wen Daniel P. Cahill Tracy T. Batchelor Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
description	Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibitor (IDH305) in 8 mutant IDH1 glioma patients.
format	article
author	Ovidiu C. Andronesi Isabel C. Arrillaga-Romany K. Ina Ly Wolfgang Bogner Eva M. Ratai Kara Reitz A. John Iafrate Jorg Dietrich Elizabeth R. Gerstner Andrew S. Chi Bruce R. Rosen Patrick Y. Wen Daniel P. Cahill Tracy T. Batchelor
author_facet	Ovidiu C. Andronesi Isabel C. Arrillaga-Romany K. Ina Ly Wolfgang Bogner Eva M. Ratai Kara Reitz A. John Iafrate Jorg Dietrich Elizabeth R. Gerstner Andrew S. Chi Bruce R. Rosen Patrick Y. Wen Daniel P. Cahill Tracy T. Batchelor
author_sort	Ovidiu C. Andronesi
title	Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
title_short	Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
title_full	Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
title_fullStr	Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
title_full_unstemmed	Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate
title_sort	pharmacodynamics of mutant-idh1 inhibitors in glioma patients probed by in vivo 3d mrs imaging of 2-hydroxyglutarate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6420b3093174f1f828f783b189caae2
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Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

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