Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.

<h4>Background and aims</h4>The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chines...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Danny Ka-Ho Wong, Tsunamasa Watanabe, Yasuhito Tanaka, Wai-Kay Seto, Cheuk-Kwong Lee, James Fung, Che-Kit Lin, Fung-Yu Huang, Ching-Lung Lai, Man-Fung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b649caf4f32b4e7b9d5d74da3fabb377
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b649caf4f32b4e7b9d5d74da3fabb377
record_format	dspace
spelling	oai:doaj.org-article:b649caf4f32b4e7b9d5d74da3fabb3772021-11-18T07:40:09ZRole of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.1932-620310.1371/journal.pone.0066920https://doaj.org/article/b649caf4f32b4e7b9d5d74da3fabb3772013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23825586/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aims</h4>The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong.<h4>Methods</h4>We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months.<h4>Results</h4>Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity.<h4>Conclusion</h4>HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.Danny Ka-Ho WongTsunamasa WatanabeYasuhito TanakaWai-Kay SetoCheuk-Kwong LeeJames FungChe-Kit LinFung-Yu HuangChing-Lung LaiMan-Fung YuenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66920 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danny Ka-Ho Wong Tsunamasa Watanabe Yasuhito Tanaka Wai-Kay Seto Cheuk-Kwong Lee James Fung Che-Kit Lin Fung-Yu Huang Ching-Lung Lai Man-Fung Yuen Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
description	<h4>Background and aims</h4>The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong.<h4>Methods</h4>We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months.<h4>Results</h4>Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity.<h4>Conclusion</h4>HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
format	article
author	Danny Ka-Ho Wong Tsunamasa Watanabe Yasuhito Tanaka Wai-Kay Seto Cheuk-Kwong Lee James Fung Che-Kit Lin Fung-Yu Huang Ching-Lung Lai Man-Fung Yuen
author_facet	Danny Ka-Ho Wong Tsunamasa Watanabe Yasuhito Tanaka Wai-Kay Seto Cheuk-Kwong Lee James Fung Che-Kit Lin Fung-Yu Huang Ching-Lung Lai Man-Fung Yuen
author_sort	Danny Ka-Ho Wong
title	Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
title_short	Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
title_full	Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
title_fullStr	Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
title_full_unstemmed	Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.
title_sort	role of hla-dp polymorphisms on chronicity and disease activity of hepatitis b infection in southern chinese.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b649caf4f32b4e7b9d5d74da3fabb377
work_keys_str_mv	AT dannykahowong roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT tsunamasawatanabe roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT yasuhitotanaka roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT waikayseto roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT cheukkwonglee roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT jamesfung roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT chekitlin roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT fungyuhuang roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT chinglunglai roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese AT manfungyuen roleofhladppolymorphismsonchronicityanddiseaseactivityofhepatitisbinfectioninsouthernchinese
_version_	1718423122175066112

Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese.

Ejemplares similares