Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity

Mixed-ligand manganese(II) complexes [Mn3(bipy)2L4(OAc)2] (1), [Mn2(dmbipy)2L2(OAc)2] (2) and [Mn(dmphen)2L2] (3), where L – 5-phenyltetrazolate anion, bipy – 2,2′-bipyridine, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, have been synthesized and characterized by elemental...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ekaterina A. Ermakova, Julia A. Eremina, Ksenia S. Smirnova, Lyubov S. Klyushova, Danila B. Kal'nyi, Taisiya S. Sukhikh, A.A. Zubenko, L.N. Fetisov, K.N. Kononenko, Elizaveta V. Lider
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Manganese(II) complexes Polypyridine 5-phenyltetrazole Cytotoxicity Antimicrobial and antioxidant activity Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b64becba6ccd460288edc6f3b7a12f2a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b64becba6ccd460288edc6f3b7a12f2a
record_format	dspace
spelling	oai:doaj.org-article:b64becba6ccd460288edc6f3b7a12f2a2021-11-20T05:05:48ZMixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity2211-715610.1016/j.rechem.2021.100239https://doaj.org/article/b64becba6ccd460288edc6f3b7a12f2a2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211715621001442https://doaj.org/toc/2211-7156Mixed-ligand manganese(II) complexes [Mn3(bipy)2L4(OAc)2] (1), [Mn2(dmbipy)2L2(OAc)2] (2) and [Mn(dmphen)2L2] (3), where L – 5-phenyltetrazolate anion, bipy – 2,2′-bipyridine, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, have been synthesized and characterized by elemental analysis, IR spectroscopy, cyclic voltammetry and powder X-ray diffraction. Single‐crystal X‐ray diffraction analysis was carried out to determine crystal structures of complexes. The UV-vis spectroscopy has been applied to show the stability of the compounds in solution. The effect of the compounds on viability of HepG2 and Hep-2 cell lines has been investigated. Complex [Mn(dmphen)2L2] was found to be the most cytotoxic with IC50 values of 5.7 ± 0.6 µM (HepG2 cells) and 8.1 ± 1.2 µM (Hep-2 cells). The antimicrobial activity of complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii. All complexes have shown protistocidal activity against C. steinii. Complexes have been found to exhibit antioxidant activity measured spectrophotometrically using ABTS•+ radical.Ekaterina A. ErmakovaJulia A. EreminaKsenia S. SmirnovaLyubov S. KlyushovaDanila B. Kal'nyiTaisiya S. SukhikhA.A. ZubenkoL.N. FetisovK.N. KononenkoElizaveta V. LiderElsevierarticleManganese(II) complexesPolypyridine5-phenyltetrazoleCytotoxicityAntimicrobial and antioxidant activityChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100239- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Manganese(II) complexes Polypyridine 5-phenyltetrazole Cytotoxicity Antimicrobial and antioxidant activity Chemistry QD1-999
spellingShingle	Manganese(II) complexes Polypyridine 5-phenyltetrazole Cytotoxicity Antimicrobial and antioxidant activity Chemistry QD1-999 Ekaterina A. Ermakova Julia A. Eremina Ksenia S. Smirnova Lyubov S. Klyushova Danila B. Kal'nyi Taisiya S. Sukhikh A.A. Zubenko L.N. Fetisov K.N. Kononenko Elizaveta V. Lider Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
description	Mixed-ligand manganese(II) complexes [Mn3(bipy)2L4(OAc)2] (1), [Mn2(dmbipy)2L2(OAc)2] (2) and [Mn(dmphen)2L2] (3), where L – 5-phenyltetrazolate anion, bipy – 2,2′-bipyridine, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, have been synthesized and characterized by elemental analysis, IR spectroscopy, cyclic voltammetry and powder X-ray diffraction. Single‐crystal X‐ray diffraction analysis was carried out to determine crystal structures of complexes. The UV-vis spectroscopy has been applied to show the stability of the compounds in solution. The effect of the compounds on viability of HepG2 and Hep-2 cell lines has been investigated. Complex [Mn(dmphen)2L2] was found to be the most cytotoxic with IC50 values of 5.7 ± 0.6 µM (HepG2 cells) and 8.1 ± 1.2 µM (Hep-2 cells). The antimicrobial activity of complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii. All complexes have shown protistocidal activity against C. steinii. Complexes have been found to exhibit antioxidant activity measured spectrophotometrically using ABTS•+ radical.
format	article
author	Ekaterina A. Ermakova Julia A. Eremina Ksenia S. Smirnova Lyubov S. Klyushova Danila B. Kal'nyi Taisiya S. Sukhikh A.A. Zubenko L.N. Fetisov K.N. Kononenko Elizaveta V. Lider
author_facet	Ekaterina A. Ermakova Julia A. Eremina Ksenia S. Smirnova Lyubov S. Klyushova Danila B. Kal'nyi Taisiya S. Sukhikh A.A. Zubenko L.N. Fetisov K.N. Kononenko Elizaveta V. Lider
author_sort	Ekaterina A. Ermakova
title	Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
title_short	Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
title_full	Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
title_fullStr	Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
title_full_unstemmed	Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity
title_sort	mixed-ligand manganese(ii) complexes with 5-phenyltetrazole and polypyridine derivatives: synthesis, crystal structures and biological activity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b64becba6ccd460288edc6f3b7a12f2a
work_keys_str_mv	AT ekaterinaaermakova mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT juliaaeremina mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT kseniassmirnova mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT lyubovsklyushova mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT danilabkalnyi mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT taisiyassukhikh mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT aazubenko mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT lnfetisov mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT knkononenko mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity AT elizavetavlider mixedligandmanganeseiicomplexeswith5phenyltetrazoleandpolypyridinederivativessynthesiscrystalstructuresandbiologicalactivity
_version_	1718419618950807552

Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity

Ejemplares similares