Right atrium size in the general population

Abstract Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study...

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Autores principales:	Karsten Keller, Christoph Sinning, Andreas Schulz, Claus Jünger, Volker H. Schmitt, Omar Hahad, Tanja Zeller, Manfred Beutel, Norbert Pfeiffer, Konstantin Strauch, Stefan Blankenberg, Karl J. Lackner, Jürgen H. Prochaska, Eberhard Schulz, Thomas Münzel, Philipp S. Wild
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b64ecdbb412c475c821a0ccc11763287
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spelling	oai:doaj.org-article:b64ecdbb412c475c821a0ccc117632872021-11-21T12:25:04ZRight atrium size in the general population10.1038/s41598-021-01968-y2045-2322https://doaj.org/article/b64ecdbb412c475c821a0ccc117632872021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01968-yhttps://doaj.org/toc/2045-2322Abstract Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th–95th: 12.7–30.4 ml/m) and 26.1 ml/m in men (5th–95th: 16.0–40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29–2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits.Karsten KellerChristoph SinningAndreas SchulzClaus JüngerVolker H. SchmittOmar HahadTanja ZellerManfred BeutelNorbert PfeifferKonstantin StrauchStefan BlankenbergKarl J. LacknerJürgen H. ProchaskaEberhard SchulzThomas MünzelPhilipp S. WildNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karsten Keller Christoph Sinning Andreas Schulz Claus Jünger Volker H. Schmitt Omar Hahad Tanja Zeller Manfred Beutel Norbert Pfeiffer Konstantin Strauch Stefan Blankenberg Karl J. Lackner Jürgen H. Prochaska Eberhard Schulz Thomas Münzel Philipp S. Wild Right atrium size in the general population
description	Abstract Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th–95th: 12.7–30.4 ml/m) and 26.1 ml/m in men (5th–95th: 16.0–40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29–2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits.
format	article
author	Karsten Keller Christoph Sinning Andreas Schulz Claus Jünger Volker H. Schmitt Omar Hahad Tanja Zeller Manfred Beutel Norbert Pfeiffer Konstantin Strauch Stefan Blankenberg Karl J. Lackner Jürgen H. Prochaska Eberhard Schulz Thomas Münzel Philipp S. Wild
author_facet	Karsten Keller Christoph Sinning Andreas Schulz Claus Jünger Volker H. Schmitt Omar Hahad Tanja Zeller Manfred Beutel Norbert Pfeiffer Konstantin Strauch Stefan Blankenberg Karl J. Lackner Jürgen H. Prochaska Eberhard Schulz Thomas Münzel Philipp S. Wild
author_sort	Karsten Keller
title	Right atrium size in the general population
title_short	Right atrium size in the general population
title_full	Right atrium size in the general population
title_fullStr	Right atrium size in the general population
title_full_unstemmed	Right atrium size in the general population
title_sort	right atrium size in the general population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b64ecdbb412c475c821a0ccc11763287
work_keys_str_mv	AT karstenkeller rightatriumsizeinthegeneralpopulation AT christophsinning rightatriumsizeinthegeneralpopulation AT andreasschulz rightatriumsizeinthegeneralpopulation AT clausjunger rightatriumsizeinthegeneralpopulation AT volkerhschmitt rightatriumsizeinthegeneralpopulation AT omarhahad rightatriumsizeinthegeneralpopulation AT tanjazeller rightatriumsizeinthegeneralpopulation AT manfredbeutel rightatriumsizeinthegeneralpopulation AT norbertpfeiffer rightatriumsizeinthegeneralpopulation AT konstantinstrauch rightatriumsizeinthegeneralpopulation AT stefanblankenberg rightatriumsizeinthegeneralpopulation AT karljlackner rightatriumsizeinthegeneralpopulation AT jurgenhprochaska rightatriumsizeinthegeneralpopulation AT eberhardschulz rightatriumsizeinthegeneralpopulation AT thomasmunzel rightatriumsizeinthegeneralpopulation AT philippswild rightatriumsizeinthegeneralpopulation
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Right atrium size in the general population

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