The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Abstract While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors wit...

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Autores principales:	Daeyoung Roh, Dong-Hee Lee, Soo Whan Kim, Sung Won Kim, Byung-Guk Kim, Do Hyun Kim, Ji-Hyeon Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6506eeb3d484d628c6814ee3187d285
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spelling	oai:doaj.org-article:b6506eeb3d484d628c6814ee3187d2852021-12-02T14:01:35ZThe association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults10.1038/s41598-020-80943-52045-2322https://doaj.org/article/b6506eeb3d484d628c6814ee3187d2852021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80943-5https://doaj.org/toc/2045-2322Abstract While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults.Daeyoung RohDong-Hee LeeSoo Whan KimSung Won KimByung-Guk KimDo Hyun KimJi-Hyeon ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daeyoung Roh Dong-Hee Lee Soo Whan Kim Sung Won Kim Byung-Guk Kim Do Hyun Kim Ji-Hyeon Shin The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
description	Abstract While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults.
format	article
author	Daeyoung Roh Dong-Hee Lee Soo Whan Kim Sung Won Kim Byung-Guk Kim Do Hyun Kim Ji-Hyeon Shin
author_facet	Daeyoung Roh Dong-Hee Lee Soo Whan Kim Sung Won Kim Byung-Guk Kim Do Hyun Kim Ji-Hyeon Shin
author_sort	Daeyoung Roh
title	The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_short	The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_full	The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_fullStr	The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_full_unstemmed	The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
title_sort	association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6506eeb3d484d628c6814ee3187d285
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The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

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