The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019

The renin–aldosterone–angiotensin system (RAAS) plays an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2 and...

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Autores principales:	Eliecer Coto, Pablo Avanzas, Juan Gómez
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b651b52bad364af988d28345d53cf8cf
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spelling	oai:doaj.org-article:b651b52bad364af988d28345d53cf8cf2021-12-04T16:04:03ZThe Renin–Angiotensin–Aldosterone System and Coronavirus Disease 201910.15420/ecr.2020.301758-37641758-3756https://doaj.org/article/b651b52bad364af988d28345d53cf8cf2021-03-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2020.30https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764The renin–aldosterone–angiotensin system (RAAS) plays an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2 and the host’s expression of this membrane-bound protein could affect susceptibility to infection. The RAAS is an important regulator of cardiovascular physiology and ACE2 has an essential role. People with hypertension and other traits have shown to have an imbalance in ACE/ACE2 levels and reduced levels of ACE2 could enhance the risk of adverse outcome in patients with COVID-19. It has been hypothesised that the RAAS may mediate the interplay between cardiovascular disease and COVID-19 severity. Evidence shows that antihypertensive drugs that target the RAAS have no significant effect on the risk of infection and disease outcome. Variations in RAAS genes have been associated with the risk of developing hypertension and cardiovascular disease and could partly explain the heterogenous response to SARS-CoV-2 infection. This article explores the interplay between the RAAS and COVID-19, with emphasis on the possible relationship between genetic variations and disease severity.Eliecer CotoPablo AvanzasJuan GómezRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Eliecer Coto Pablo Avanzas Juan Gómez The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
description	The renin–aldosterone–angiotensin system (RAAS) plays an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2 and the host’s expression of this membrane-bound protein could affect susceptibility to infection. The RAAS is an important regulator of cardiovascular physiology and ACE2 has an essential role. People with hypertension and other traits have shown to have an imbalance in ACE/ACE2 levels and reduced levels of ACE2 could enhance the risk of adverse outcome in patients with COVID-19. It has been hypothesised that the RAAS may mediate the interplay between cardiovascular disease and COVID-19 severity. Evidence shows that antihypertensive drugs that target the RAAS have no significant effect on the risk of infection and disease outcome. Variations in RAAS genes have been associated with the risk of developing hypertension and cardiovascular disease and could partly explain the heterogenous response to SARS-CoV-2 infection. This article explores the interplay between the RAAS and COVID-19, with emphasis on the possible relationship between genetic variations and disease severity.
format	article
author	Eliecer Coto Pablo Avanzas Juan Gómez
author_facet	Eliecer Coto Pablo Avanzas Juan Gómez
author_sort	Eliecer Coto
title	The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
title_short	The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
title_full	The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
title_fullStr	The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
title_full_unstemmed	The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019
title_sort	renin–angiotensin–aldosterone system and coronavirus disease 2019
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/b651b52bad364af988d28345d53cf8cf
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The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019

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