Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica

Kyoung-Min Kim,1 Hye Min Kim,1 Won-Jae Lee,2 Chang-Woo Lee,3 Tae-il Kim,4 Jong-Kwon Lee,5 Jayoung Jeong,5 Seung-Min Paek,2 Jae-Min Oh1 1Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea; 2Department of Chemistry, Kyung...

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Autores principales:	Kim KM, Kim HM, Lee WJ, Lee CW, Kim TI, Lee JK, Jeong J, Paek SM, Oh JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b652fd8cd9c8434eb28635f00f5f7c1d
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spelling	oai:doaj.org-article:b652fd8cd9c8434eb28635f00f5f7c1d2021-12-02T01:32:09ZSurface treatment of silica nanoparticles for stable and charge-controlled colloidal silica1178-2013https://doaj.org/article/b652fd8cd9c8434eb28635f00f5f7c1d2014-12-01T00:00:00Zhttp://www.dovepress.com/surface-treatment-of-silica-nanoparticles-for-stable-and-charge-contro-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Kyoung-Min Kim,1 Hye Min Kim,1 Won-Jae Lee,2 Chang-Woo Lee,3 Tae-il Kim,4 Jong-Kwon Lee,5 Jayoung Jeong,5 Seung-Min Paek,2 Jae-Min Oh1 1Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea; 2Department of Chemistry, Kyungpook National University, Taegu, Republic of Korea; 3Battelle-Korea Laboratory, International Center for Converging Technology, Korea University, Seoul, Republic of Korea; 4Department of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea; 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, Republic of Korea Abstract: An attempt was made to control the surface charge of colloidal silica nanoparticles with 20 nm and 100 nm diameters. Untreated silica nanoparticles were determined to be highly negatively charged and have stable hydrodynamic sizes in a wide pH range. To change the surface to a positively charged form, various coating agents, such as amine containing molecules, multivalent metal cation, or amino acids, were used to treat the colloidal silica nanoparticles. Molecules with chelating amine sites were determined to have high affinity with the silica surface to make agglomerations or gel-like networks. Amino acid coatings resulted in relatively stable silica colloids with a modified surface charge. Three amino acid moiety coatings (L-serine, L-histidine, and L-arginine) exhibited surface charge modifying efficacy of L-histidine > L-arginine > L-serine and hydrodynamic size preservation efficacy of L-serine > L-arginine > L-histidine. The time dependent change in L-arginine coated colloidal silica was investigated by measuring the pattern of the backscattered light in a Turbiscan™. The results indicated that both the 20 nm and 100 nm L-arginine coated silica samples were fairly stable in terms of colloidal homogeneity, showing only slight coalescence and sedimentation. Keywords: silica, nanoparticles, surface charge, colloidal stability, turbidity, amino acidsKim KMKim HMLee WJLee CWKim TILee JKJeong JPaek SMOh JMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 2, Pp 29-40 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kim KM Kim HM Lee WJ Lee CW Kim TI Lee JK Jeong J Paek SM Oh JM Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
description	Kyoung-Min Kim,1 Hye Min Kim,1 Won-Jae Lee,2 Chang-Woo Lee,3 Tae-il Kim,4 Jong-Kwon Lee,5 Jayoung Jeong,5 Seung-Min Paek,2 Jae-Min Oh1 1Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, Republic of Korea; 2Department of Chemistry, Kyungpook National University, Taegu, Republic of Korea; 3Battelle-Korea Laboratory, International Center for Converging Technology, Korea University, Seoul, Republic of Korea; 4Department of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea; 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, Republic of Korea Abstract: An attempt was made to control the surface charge of colloidal silica nanoparticles with 20 nm and 100 nm diameters. Untreated silica nanoparticles were determined to be highly negatively charged and have stable hydrodynamic sizes in a wide pH range. To change the surface to a positively charged form, various coating agents, such as amine containing molecules, multivalent metal cation, or amino acids, were used to treat the colloidal silica nanoparticles. Molecules with chelating amine sites were determined to have high affinity with the silica surface to make agglomerations or gel-like networks. Amino acid coatings resulted in relatively stable silica colloids with a modified surface charge. Three amino acid moiety coatings (L-serine, L-histidine, and L-arginine) exhibited surface charge modifying efficacy of L-histidine > L-arginine > L-serine and hydrodynamic size preservation efficacy of L-serine > L-arginine > L-histidine. The time dependent change in L-arginine coated colloidal silica was investigated by measuring the pattern of the backscattered light in a Turbiscan™. The results indicated that both the 20 nm and 100 nm L-arginine coated silica samples were fairly stable in terms of colloidal homogeneity, showing only slight coalescence and sedimentation. Keywords: silica, nanoparticles, surface charge, colloidal stability, turbidity, amino acids
format	article
author	Kim KM Kim HM Lee WJ Lee CW Kim TI Lee JK Jeong J Paek SM Oh JM
author_facet	Kim KM Kim HM Lee WJ Lee CW Kim TI Lee JK Jeong J Paek SM Oh JM
author_sort	Kim KM
title	Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
title_short	Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
title_full	Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
title_fullStr	Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
title_full_unstemmed	Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
title_sort	surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b652fd8cd9c8434eb28635f00f5f7c1d
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Surface treatment of silica nanoparticles for stable and charge-controlled colloidal silica

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