Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors

Yi Zhao, Haojie Xie, Chunyang Pan, Yaobing Yao, Zhe Gong, Yanfei Li, Yanjie Jia Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yanjie JiaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou Un...

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Autores principales:	Zhao Y, Xie H, Pan C, Yao Y, Gong Z, Li Y, Jia Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cerebral hemorrhage clinical features malignant tumor risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b65814db536340d992664186ce32f9ba
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spelling	oai:doaj.org-article:b65814db536340d992664186ce32f9ba2021-12-02T16:45:32ZClinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors1178-2021https://doaj.org/article/b65814db536340d992664186ce32f9ba2021-08-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-and-risk-factors-of-cerebral-hemorrhage-in-pa-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Yi Zhao, Haojie Xie, Chunyang Pan, Yaobing Yao, Zhe Gong, Yanfei Li, Yanjie Jia Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yanjie JiaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, 1st Jian She East Road, Zhengzhou, 450052, People’s Republic of ChinaTel +86-135 13802916Email jiayanjie1971@zzu.edu.cnPropose: To investigate the clinical characteristics and potential risk factors of the first onset of cerebral hemorrhage in patients with occult malignant tumors.Patients and methods: In this retrospective study, 23 patients with occult malignant tumors with the first onset of cerebral hemorrhage were enrolled in the tumor group, and 92 patients without occult tumors in the same period were enrolled in the control group. There were no statistical differences in age and sex between both groups by propensity score matching. Collected clinical data included age, sex, smoking history, drinking history, hypertension history, diabetes history, past medical history, routine blood tests, neutrophil-to-lymphocyte ratio (NLR), liver and kidney function, fasting blood glucose level, coagulation function, tumor markers, imaging examinations, National Institute of Health stroke scale (NIHSS) score on admission, modified Rankin Scale (mRS) score 90 days after intracerebral hemorrhage and final mRS score.Results: Compared with the control group, the tumor group had fewer patients with hypertension (52.2% vs 81.5%, P< 0.05), and the NLR was significantly decreased in the tumor group (2.74 vs 5.46, P< 0.05). The tumor group had a greater number of patients with the bleeding sites located in the lobar regions (43.5% vs.19.6%, P< 0.05) and a higher coagulation dysfunction (52.2% vs 29.3%, P< 0.05) than the control group. Multivariate logistic regression analysis revealed that no history of hypertension (OR: 3.141, 95% CI: 1.107– 8.916), lobar cerebral hemorrhage (OR: 3.465 95% CI:1.172– 10.243), and coagulation dysfunction (OR: 3.176, 95% CI: 1.131– 8.913) were independent predictors of occult tumors, and the receiver operating characteristic (ROC) curve showed that the area under the curve of the three-index combined diagnosis was 0.748, C-statistic analysis also showed the same result.Conclusion: No history of hypertension, lobar cerebral hemorrhage, and coagulation dysfunction may be predictors of the risk of occult malignancies in patients with cerebral hemorrhage.Keywords: cerebral hemorrhage, clinical features, malignant tumor, risk factorsZhao YXie HPan CYao YGong ZLi YJia YDove Medical Pressarticlecerebral hemorrhageclinical featuresmalignant tumorrisk factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2729-2738 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral hemorrhage clinical features malignant tumor risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cerebral hemorrhage clinical features malignant tumor risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhao Y Xie H Pan C Yao Y Gong Z Li Y Jia Y Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
description	Yi Zhao, Haojie Xie, Chunyang Pan, Yaobing Yao, Zhe Gong, Yanfei Li, Yanjie Jia Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Yanjie JiaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, 1st Jian She East Road, Zhengzhou, 450052, People’s Republic of ChinaTel +86-135 13802916Email jiayanjie1971@zzu.edu.cnPropose: To investigate the clinical characteristics and potential risk factors of the first onset of cerebral hemorrhage in patients with occult malignant tumors.Patients and methods: In this retrospective study, 23 patients with occult malignant tumors with the first onset of cerebral hemorrhage were enrolled in the tumor group, and 92 patients without occult tumors in the same period were enrolled in the control group. There were no statistical differences in age and sex between both groups by propensity score matching. Collected clinical data included age, sex, smoking history, drinking history, hypertension history, diabetes history, past medical history, routine blood tests, neutrophil-to-lymphocyte ratio (NLR), liver and kidney function, fasting blood glucose level, coagulation function, tumor markers, imaging examinations, National Institute of Health stroke scale (NIHSS) score on admission, modified Rankin Scale (mRS) score 90 days after intracerebral hemorrhage and final mRS score.Results: Compared with the control group, the tumor group had fewer patients with hypertension (52.2% vs 81.5%, P< 0.05), and the NLR was significantly decreased in the tumor group (2.74 vs 5.46, P< 0.05). The tumor group had a greater number of patients with the bleeding sites located in the lobar regions (43.5% vs.19.6%, P< 0.05) and a higher coagulation dysfunction (52.2% vs 29.3%, P< 0.05) than the control group. Multivariate logistic regression analysis revealed that no history of hypertension (OR: 3.141, 95% CI: 1.107– 8.916), lobar cerebral hemorrhage (OR: 3.465 95% CI:1.172– 10.243), and coagulation dysfunction (OR: 3.176, 95% CI: 1.131– 8.913) were independent predictors of occult tumors, and the receiver operating characteristic (ROC) curve showed that the area under the curve of the three-index combined diagnosis was 0.748, C-statistic analysis also showed the same result.Conclusion: No history of hypertension, lobar cerebral hemorrhage, and coagulation dysfunction may be predictors of the risk of occult malignancies in patients with cerebral hemorrhage.Keywords: cerebral hemorrhage, clinical features, malignant tumor, risk factors
format	article
author	Zhao Y Xie H Pan C Yao Y Gong Z Li Y Jia Y
author_facet	Zhao Y Xie H Pan C Yao Y Gong Z Li Y Jia Y
author_sort	Zhao Y
title	Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
title_short	Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
title_full	Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
title_fullStr	Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
title_full_unstemmed	Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors
title_sort	clinical characteristics and risk factors of cerebral hemorrhage in patients with occult malignant tumors
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b65814db536340d992664186ce32f9ba
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Clinical Characteristics and Risk Factors of Cerebral Hemorrhage in Patients with Occult Malignant Tumors

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