Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.
<h4>Background</h4>Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model.<h4>Methodology/princip...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2009
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b65921f2bf664cfdb0ae6713d59bfa0a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b65921f2bf664cfdb0ae6713d59bfa0a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b65921f2bf664cfdb0ae6713d59bfa0a2021-12-02T20:12:07ZGastrointestinal hyperplasia with altered expression of DNA polymerase beta.1932-620310.1371/journal.pone.0006493https://doaj.org/article/b65921f2bf664cfdb0ae6713d59bfa0a2009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19654874/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model.<h4>Methodology/principal findings</h4>We have recently developed a novel transgenic mouse model that over-expresses Pol beta. These mice present with an elevated incidence of spontaneous histologic lesions, including cataracts, hyperplasia of Brunner's gland and mucosal hyperplasia in the duodenum. In addition, osteogenic tumors in mice tails, such as osteoma and osteosarcoma were detected. This is the first report of elevated tumor incidence in a mouse model of Pol beta over-expression. These findings prompted an evaluation of human gastrointestinal tumors with regard to Pol beta expression. We observed elevated expression of Pol beta in stomach adenomas and thyroid follicular carcinomas, but reduced Pol beta expression in esophageal adenocarcinomas and squamous carcinomas.<h4>Conclusions/significance</h4>These data support the hypothesis that balanced and proficient base excision repair protein expression and base excision repair capacity is required for genome stability and protection from hyperplasia and tumor formation.Katsuhiko YoshizawaElena JelezcovaAshley R BrownJulie F FoleyAbraham NyskaXiangli CuiLorne J HofsethRobert M MaronpotSamuel H WilsonAntonia R SepulvedaRobert W SobolPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6493 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Katsuhiko Yoshizawa Elena Jelezcova Ashley R Brown Julie F Foley Abraham Nyska Xiangli Cui Lorne J Hofseth Robert M Maronpot Samuel H Wilson Antonia R Sepulveda Robert W Sobol Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| description |
<h4>Background</h4>Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model.<h4>Methodology/principal findings</h4>We have recently developed a novel transgenic mouse model that over-expresses Pol beta. These mice present with an elevated incidence of spontaneous histologic lesions, including cataracts, hyperplasia of Brunner's gland and mucosal hyperplasia in the duodenum. In addition, osteogenic tumors in mice tails, such as osteoma and osteosarcoma were detected. This is the first report of elevated tumor incidence in a mouse model of Pol beta over-expression. These findings prompted an evaluation of human gastrointestinal tumors with regard to Pol beta expression. We observed elevated expression of Pol beta in stomach adenomas and thyroid follicular carcinomas, but reduced Pol beta expression in esophageal adenocarcinomas and squamous carcinomas.<h4>Conclusions/significance</h4>These data support the hypothesis that balanced and proficient base excision repair protein expression and base excision repair capacity is required for genome stability and protection from hyperplasia and tumor formation. |
| format |
article |
| author |
Katsuhiko Yoshizawa Elena Jelezcova Ashley R Brown Julie F Foley Abraham Nyska Xiangli Cui Lorne J Hofseth Robert M Maronpot Samuel H Wilson Antonia R Sepulveda Robert W Sobol |
| author_facet |
Katsuhiko Yoshizawa Elena Jelezcova Ashley R Brown Julie F Foley Abraham Nyska Xiangli Cui Lorne J Hofseth Robert M Maronpot Samuel H Wilson Antonia R Sepulveda Robert W Sobol |
| author_sort |
Katsuhiko Yoshizawa |
| title |
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| title_short |
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| title_full |
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| title_fullStr |
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| title_full_unstemmed |
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. |
| title_sort |
gastrointestinal hyperplasia with altered expression of dna polymerase beta. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/b65921f2bf664cfdb0ae6713d59bfa0a |
| work_keys_str_mv |
AT katsuhikoyoshizawa gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT elenajelezcova gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT ashleyrbrown gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT julieffoley gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT abrahamnyska gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT xianglicui gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT lornejhofseth gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT robertmmaronpot gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT samuelhwilson gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT antoniarsepulveda gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta AT robertwsobol gastrointestinalhyperplasiawithalteredexpressionofdnapolymerasebeta |
| _version_ |
1718374905648513024 |