Effects of L-dopa during auditory instrumental learning in humans.

The dopaminergic neurotransmitter system is critically involved in promoting plasticity in auditory cortex. We combined functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to investigate dopaminergic modulation of neural activity in auditory cortex during instrumental lea...

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Autores principales:	Tina Weis, Sebastian Puschmann, Andre Brechmann, Christiane M Thiel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b65b0ec370254c9d856080e10ccf4c1b
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id	oai:doaj.org-article:b65b0ec370254c9d856080e10ccf4c1b
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spelling	oai:doaj.org-article:b65b0ec370254c9d856080e10ccf4c1b2021-11-18T08:03:53ZEffects of L-dopa during auditory instrumental learning in humans.1932-620310.1371/journal.pone.0052504https://doaj.org/article/b65b0ec370254c9d856080e10ccf4c1b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285070/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The dopaminergic neurotransmitter system is critically involved in promoting plasticity in auditory cortex. We combined functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to investigate dopaminergic modulation of neural activity in auditory cortex during instrumental learning. Volunteers either received 100 mg L-dopa (Madopar) or placebo in an appetitive, differential instrumental conditioning paradigm, which involved learning that a specific category of frequency modulated tones predicts a monetary reward when fast responses were made in a subsequent reaction time task. The other category of frequency modulated tones was not related to a reward. Our behavioral data provides evidence that dopaminergic stimulation differentially impacts on the speed of instrumental responding in rewarded and unrewarded trials. L-dopa increased neural BOLD activity in left auditory cortex to tones in rewarded and unrewarded trials. This increase was related to plasma L-dopa levels and learning rate. Our data thus provides evidence for dopaminergic modulation of neural activity in auditory cortex, which occurs for both auditory stimuli related to a later reward and those not related to a reward.Tina WeisSebastian PuschmannAndre BrechmannChristiane M ThielPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52504 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina Weis Sebastian Puschmann Andre Brechmann Christiane M Thiel Effects of L-dopa during auditory instrumental learning in humans.
description	The dopaminergic neurotransmitter system is critically involved in promoting plasticity in auditory cortex. We combined functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to investigate dopaminergic modulation of neural activity in auditory cortex during instrumental learning. Volunteers either received 100 mg L-dopa (Madopar) or placebo in an appetitive, differential instrumental conditioning paradigm, which involved learning that a specific category of frequency modulated tones predicts a monetary reward when fast responses were made in a subsequent reaction time task. The other category of frequency modulated tones was not related to a reward. Our behavioral data provides evidence that dopaminergic stimulation differentially impacts on the speed of instrumental responding in rewarded and unrewarded trials. L-dopa increased neural BOLD activity in left auditory cortex to tones in rewarded and unrewarded trials. This increase was related to plasma L-dopa levels and learning rate. Our data thus provides evidence for dopaminergic modulation of neural activity in auditory cortex, which occurs for both auditory stimuli related to a later reward and those not related to a reward.
format	article
author	Tina Weis Sebastian Puschmann Andre Brechmann Christiane M Thiel
author_facet	Tina Weis Sebastian Puschmann Andre Brechmann Christiane M Thiel
author_sort	Tina Weis
title	Effects of L-dopa during auditory instrumental learning in humans.
title_short	Effects of L-dopa during auditory instrumental learning in humans.
title_full	Effects of L-dopa during auditory instrumental learning in humans.
title_fullStr	Effects of L-dopa during auditory instrumental learning in humans.
title_full_unstemmed	Effects of L-dopa during auditory instrumental learning in humans.
title_sort	effects of l-dopa during auditory instrumental learning in humans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b65b0ec370254c9d856080e10ccf4c1b
work_keys_str_mv	AT tinaweis effectsofldopaduringauditoryinstrumentallearninginhumans AT sebastianpuschmann effectsofldopaduringauditoryinstrumentallearninginhumans AT andrebrechmann effectsofldopaduringauditoryinstrumentallearninginhumans AT christianemthiel effectsofldopaduringauditoryinstrumentallearninginhumans
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Effects of L-dopa during auditory instrumental learning in humans.

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