Radionuclide carriers for targeting of cancer

Stavroula SofouLaboratory for Drug Delivery Systems, Othmer-Jacobs Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USAAbstract: This review describes strategies for the delivery of therapeutic radionuclides to tumor sites. Therapeutic approaches are summarize...

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Autor principal:	Stavroula Sofou
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b65b86097b80470c99656d6d29a8cc07
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spelling	oai:doaj.org-article:b65b86097b80470c99656d6d29a8cc072021-12-02T05:09:47ZRadionuclide carriers for targeting of cancer1176-91141178-2013https://doaj.org/article/b65b86097b80470c99656d6d29a8cc072008-06-01T00:00:00Zhttp://www.dovepress.com/radionuclide-carriers-for-targeting-of-cancer-a1839https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Stavroula SofouLaboratory for Drug Delivery Systems, Othmer-Jacobs Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USAAbstract: This review describes strategies for the delivery of therapeutic radionuclides to tumor sites. Therapeutic approaches are summarized in terms of tumor location in the body, and tumor morphology. These determine the radionuclides of choice for suggested targeting ligands, and the type of delivery carriers. This review is not exhaustive in examples of radionuclide carriers for targeted cancer therapy. Our purpose is two-fold: to give an integrated picture of the general strategies and molecular constructs currently explored for the delivery of therapeutic radionuclides, and to identify challenges that need to be addressed. Internal radiotherapies for targeting of cancer are at a very exciting and creative stage. It is expected that the current emphasis on multidisciplinary approaches for exploring such therapeutic directions should enable internal radiotherapy to reach its full potential.Keywords: cancer radiotherapy, targeted radiotherapy, radiotherapy of micrometastases, radiotherapy of solid tumors, radiotherapy of tumor vasculature Stavroula SofouDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 2, Pp 181-199 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Stavroula Sofou Radionuclide carriers for targeting of cancer
description	Stavroula SofouLaboratory for Drug Delivery Systems, Othmer-Jacobs Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USAAbstract: This review describes strategies for the delivery of therapeutic radionuclides to tumor sites. Therapeutic approaches are summarized in terms of tumor location in the body, and tumor morphology. These determine the radionuclides of choice for suggested targeting ligands, and the type of delivery carriers. This review is not exhaustive in examples of radionuclide carriers for targeted cancer therapy. Our purpose is two-fold: to give an integrated picture of the general strategies and molecular constructs currently explored for the delivery of therapeutic radionuclides, and to identify challenges that need to be addressed. Internal radiotherapies for targeting of cancer are at a very exciting and creative stage. It is expected that the current emphasis on multidisciplinary approaches for exploring such therapeutic directions should enable internal radiotherapy to reach its full potential.Keywords: cancer radiotherapy, targeted radiotherapy, radiotherapy of micrometastases, radiotherapy of solid tumors, radiotherapy of tumor vasculature
format	article
author	Stavroula Sofou
author_facet	Stavroula Sofou
author_sort	Stavroula Sofou
title	Radionuclide carriers for targeting of cancer
title_short	Radionuclide carriers for targeting of cancer
title_full	Radionuclide carriers for targeting of cancer
title_fullStr	Radionuclide carriers for targeting of cancer
title_full_unstemmed	Radionuclide carriers for targeting of cancer
title_sort	radionuclide carriers for targeting of cancer
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b65b86097b80470c99656d6d29a8cc07
work_keys_str_mv	AT stavroulasofou radionuclidecarriersfortargetingofcancer
_version_	1718400555230953472

Radionuclide carriers for targeting of cancer

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