Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient

Asad Makhani,1 Miriam Thake,2 William Gibson1 1University of Alberta, Division of Geriatric Medicine, Edmonton, Alberta, Canada; 2Great Western Hospitals NHS Foundation Trust, Swindon SN3 6BB, UKCorrespondence: William GibsonUniversity of Alberta, Division of Geriatric Medicine, 1-198 Clinical Scien...

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Autores principales:	Makhani A, Thake M, Gibson W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	overactive bladder mirabegron elderly ageing anticholinergic urinary incontinence. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b65e6b143e1944148ed126181816220e
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spelling	oai:doaj.org-article:b65e6b143e1944148ed126181816220e2021-12-02T15:21:30ZMirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient1178-1998https://doaj.org/article/b65e6b143e1944148ed126181816220e2020-04-01T00:00:00Zhttps://www.dovepress.com/mirabegron-in-the-treatment-of-overactive-bladder-safety-and-efficacy--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Asad Makhani,1 Miriam Thake,2 William Gibson1 1University of Alberta, Division of Geriatric Medicine, Edmonton, Alberta, Canada; 2Great Western Hospitals NHS Foundation Trust, Swindon SN3 6BB, UKCorrespondence: William GibsonUniversity of Alberta, Division of Geriatric Medicine, 1-198 Clinical Sciences Building, 11350 83 Ave, Edmonton, Alberta Tel +1 780 248 1969Email wgibson@ualberta.caAbstract: Lower urinary tract symptoms, including urgency, urgency incontinence, frequency, and nocturia, are highly prevalent in older adults and are associated with significant morbidity and impairment in quality of life. When conservative measures such as bladder training fail to improve symptoms, pharmacological management is recommended by national and international guidelines. Mirabegron, an agonist of the β 3 adrenergic receptor, demonstrates similar efficacy to the anticholinergic drugs without the risk of anticholinergic effects, but experience and evidence in the very elderly population are limited. This narrative review examines the current evidence base for mirabegron in very elderly adults.Keywords: overactive bladder, mirabegron, elderly, ageing, anticholinergic, urinary incontinenceMakhani AThake MGibson WDove Medical Pressarticleoveractive bladdermirabegronelderlyageinganticholinergicurinary incontinence.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 575-581 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	overactive bladder mirabegron elderly ageing anticholinergic urinary incontinence. Geriatrics RC952-954.6
spellingShingle	overactive bladder mirabegron elderly ageing anticholinergic urinary incontinence. Geriatrics RC952-954.6 Makhani A Thake M Gibson W Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
description	Asad Makhani,1 Miriam Thake,2 William Gibson1 1University of Alberta, Division of Geriatric Medicine, Edmonton, Alberta, Canada; 2Great Western Hospitals NHS Foundation Trust, Swindon SN3 6BB, UKCorrespondence: William GibsonUniversity of Alberta, Division of Geriatric Medicine, 1-198 Clinical Sciences Building, 11350 83 Ave, Edmonton, Alberta Tel +1 780 248 1969Email wgibson@ualberta.caAbstract: Lower urinary tract symptoms, including urgency, urgency incontinence, frequency, and nocturia, are highly prevalent in older adults and are associated with significant morbidity and impairment in quality of life. When conservative measures such as bladder training fail to improve symptoms, pharmacological management is recommended by national and international guidelines. Mirabegron, an agonist of the β 3 adrenergic receptor, demonstrates similar efficacy to the anticholinergic drugs without the risk of anticholinergic effects, but experience and evidence in the very elderly population are limited. This narrative review examines the current evidence base for mirabegron in very elderly adults.Keywords: overactive bladder, mirabegron, elderly, ageing, anticholinergic, urinary incontinence
format	article
author	Makhani A Thake M Gibson W
author_facet	Makhani A Thake M Gibson W
author_sort	Makhani A
title	Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
title_short	Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
title_full	Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
title_fullStr	Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
title_full_unstemmed	Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient
title_sort	mirabegron in the treatment of overactive bladder: safety and efficacy in the very elderly patient
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b65e6b143e1944148ed126181816220e
work_keys_str_mv	AT makhania mirabegroninthetreatmentofoveractivebladdersafetyandefficacyintheveryelderlypatient AT thakem mirabegroninthetreatmentofoveractivebladdersafetyandefficacyintheveryelderlypatient AT gibsonw mirabegroninthetreatmentofoveractivebladdersafetyandefficacyintheveryelderlypatient
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Mirabegron in the Treatment of Overactive Bladder: Safety and Efficacy in the Very Elderly Patient

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