Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation

Abstract Intestinal microbiota (IM) diversity and composition regulates host immunity and affects outcomes after allogeneic stem cell transplantation (allo-HSCT). We evaluated if the oral mucosa microbiota (OM) could impact the outcomes in patients who underwent allo-HSCT. Samples from the oral muco...

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Autores principales:	Vinícius Campos de Molla, Vitor Heidrich, Julia Stephanie Bruno, Franciele Hinterholz Knebel, Wanessa Miranda-Silva, Paula Fontes Asprino, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Anamaria Aranha Camargo, Eduardo Rodrigues Fregnani, Celso Arrais-Rodrigues
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b65ef936c8404a41ac0866b582e56345
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spelling	oai:doaj.org-article:b65ef936c8404a41ac0866b582e563452021-12-02T17:51:31ZDisruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation10.1038/s41598-021-96939-82045-2322https://doaj.org/article/b65ef936c8404a41ac0866b582e563452021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96939-8https://doaj.org/toc/2045-2322Abstract Intestinal microbiota (IM) diversity and composition regulates host immunity and affects outcomes after allogeneic stem cell transplantation (allo-HSCT). We evaluated if the oral mucosa microbiota (OM) could impact the outcomes in patients who underwent allo-HSCT. Samples from the oral mucosa of 30 patients were collected at three time points: before the conditioning regimen, at aplasia, and at engraftment. We analyzed the associations of OM diversity and composition with allo-HSCT outcomes. Lower OM diversity at preconditioning was associated with a higher risk of relapse at 3 years (68% versus 33%, respectively; P = 0.04). Dominance (relative abundance ≥ 30%) by a single genus at preconditioning was also associated with a higher risk of relapse (63% versus 36% at 3 years, respectively; P = 0.04), as well as worse progression-free survival (PFS; 19% versus 55%, respectively; P = 0.01), and overall survival (OS) at 3 years (38% versus 81%, respectively; P = 0.02). In our study we observed that OM dysbiosis is associated with a higher risk of relapse and worse survival after allo-HSCT.Vinícius Campos de MollaVitor HeidrichJulia Stephanie BrunoFranciele Hinterholz KnebelWanessa Miranda-SilvaPaula Fontes AsprinoLuciana TucunduvaVanderson RochaYana NovisAnamaria Aranha CamargoEduardo Rodrigues FregnaniCelso Arrais-RodriguesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vinícius Campos de Molla Vitor Heidrich Julia Stephanie Bruno Franciele Hinterholz Knebel Wanessa Miranda-Silva Paula Fontes Asprino Luciana Tucunduva Vanderson Rocha Yana Novis Anamaria Aranha Camargo Eduardo Rodrigues Fregnani Celso Arrais-Rodrigues Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
description	Abstract Intestinal microbiota (IM) diversity and composition regulates host immunity and affects outcomes after allogeneic stem cell transplantation (allo-HSCT). We evaluated if the oral mucosa microbiota (OM) could impact the outcomes in patients who underwent allo-HSCT. Samples from the oral mucosa of 30 patients were collected at three time points: before the conditioning regimen, at aplasia, and at engraftment. We analyzed the associations of OM diversity and composition with allo-HSCT outcomes. Lower OM diversity at preconditioning was associated with a higher risk of relapse at 3 years (68% versus 33%, respectively; P = 0.04). Dominance (relative abundance ≥ 30%) by a single genus at preconditioning was also associated with a higher risk of relapse (63% versus 36% at 3 years, respectively; P = 0.04), as well as worse progression-free survival (PFS; 19% versus 55%, respectively; P = 0.01), and overall survival (OS) at 3 years (38% versus 81%, respectively; P = 0.02). In our study we observed that OM dysbiosis is associated with a higher risk of relapse and worse survival after allo-HSCT.
format	article
author	Vinícius Campos de Molla Vitor Heidrich Julia Stephanie Bruno Franciele Hinterholz Knebel Wanessa Miranda-Silva Paula Fontes Asprino Luciana Tucunduva Vanderson Rocha Yana Novis Anamaria Aranha Camargo Eduardo Rodrigues Fregnani Celso Arrais-Rodrigues
author_facet	Vinícius Campos de Molla Vitor Heidrich Julia Stephanie Bruno Franciele Hinterholz Knebel Wanessa Miranda-Silva Paula Fontes Asprino Luciana Tucunduva Vanderson Rocha Yana Novis Anamaria Aranha Camargo Eduardo Rodrigues Fregnani Celso Arrais-Rodrigues
author_sort	Vinícius Campos de Molla
title	Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
title_short	Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
title_full	Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
title_fullStr	Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
title_full_unstemmed	Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
title_sort	disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b65ef936c8404a41ac0866b582e56345
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Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation

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