The RhoA dependent anti-metastatic function of RKIP in breast cancer

QR Code

The RhoA dependent anti-metastatic function of RKIP in breast cancer

Abstract Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis. Yet, the molecular mechanism through which RKIP executes its effects is not completely defined. RhoA...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Gardiyawasam Kalpana, Christopher Figy, Jingwei Feng, Claire Tipton, Julius N. De Castro, Vu N. Bach, Clariza Borile, Alexandria LaSalla, Hussain N. Odeh, Miranda Yeung, Rafael Garcia-Mata, Kam C. Yeung
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/b66068fddf0e4d31bf3c96e3e386a80c
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.
par: Jason Z Zhang, et autres
Publié: (2020)

RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts
par: Meichao Gu, et autres
Publié: (2017)

The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA
par: Elena E. Gorbunova, et autres
Publié: (2016)

ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA.
par: Ying Sun, et autres
Publié: (2012)

Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
par: Patrick W. Oakes, et autres
Publié: (2017)

RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A
par: Lukas Richter, et autres
Publié: (2020)

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
par: Cécile Gaston, et autres
Publié: (2021)

AAMP promotes colorectal cancermetastasis by suppressing SMURF2-mediatedubiquitination and degradation of RhoA
par: Yuhui Wu, et autres
Publié: (2021)

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.
par: Andrea Babelova, et autres
Publié: (2013)

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system.
par: Raf Ponsaerts, et autres
Publié: (2012)

Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
par: Kossay Zaoui, et autres
Publié: (2019)

Upregulation of miR-345-5p suppresses cell growth of lung adenocarcinoma by regulating ras homolog family member A (RhoA) and Rho/Rho associated protein kinase (Rho/ROCK) pathway
par: Qiao-Yun Zhou, et autres
Publié: (2021)

Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
par: Rachel McMullan, et autres
Publié: (2012)

Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway
par: Li Ning, et autres
Publié: (2021)

Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
par: Olga Martinho, et autres
Publié: (2012)

RhoA- and Cdc42-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes.
par: Benoit Dehapiot, et autres
Publié: (2021)

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
par: Sebastian Dütting, et autres
Publié: (2017)

Author Correction: Cigarette smoke induces endoplasmic reticulum stress and suppresses efferocytosis through the activation of RhoA
par: Hiroyuki Ito, et autres
Publié: (2021)

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
par: Brett A. McCray, et autres
Publié: (2021)

RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
par: Changjun Li, et autres
Publié: (2016)

Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi
par: L. Atkinson, et autres
Publié: (2018)

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
par: Robert A.H. van de Ven, et autres
Publié: (2016)

Herb-Partitioned Moxibustion Improves Crohn’s Disease-Associated Intestinal Fibrosis by Suppressing the RhoA/ROCK1/MLC Pathway
par: Min Zhao, et autres
Publié: (2021)

Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes
par: Ece Öztürk, et autres
Publié: (2017)

A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.
par: Lina Guerra, et autres
Publié: (2008)

Nrf2 regulates cell motility through RhoA–ROCK1 signalling in non-small-cell lung cancer cells
par: Eunsun Ko, et autres
Publié: (2021)

Correction: Corrigendum: p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
par: Robert A. H. van de Ven, et autres
Publié: (2017)

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
par: Niels Heemskerk, et autres
Publié: (2016)

proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model
par: Bangkun Yang, et autres
Publié: (2021)

HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
par: Lei Ke, et autres
Publié: (2011)

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
par: Hamish Campbell, et autres
Publié: (2018)

Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
par: Anne N Shemon, et autres
Publié: (2010)

Author Correction: Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation
par: Chih-Cheng Chang, et autres
Publié: (2020)

“Yiqi Huayu, Wenyang Lishui” Prescription (YHWLP) Improves the Symptoms of Chronic Obstructive Pulmonary Disease-Induced Chronic Pulmonary Heart Disease by Inhibiting the RhoA/ROCK Signaling Pathway
par: Hui Huang, et autres
Publié: (2021)

Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34 <sup>+</sup> Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome
par: Nicole L. Diggins, et autres
Publié: (2021)

Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2).
par: Jeong-Hun Kang, et autres
Publié: (2011)

LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP [Expression of Concern]
par: Gong Z, et autres
Publié: (2021)

Influence of ARHGEF3 and RHOA knockdown on ACTA2 and other genes in osteoblasts and osteoclasts.
par: Benjamin H Mullin, et autres
Publié: (2014)

RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
par: Timothy S. Catlett, et autres
Publié: (2021)

Selectivity Determinants of RHO GTPase Binding to IQGAPs
par: Niloufar Mosaddeghzadeh, et autres
Publié: (2021)