Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

The ER is subject to autophagy (ER-phagy) for turnover, with Atg40 acting as a receptor to sequester ER with Atg8 in autophagosomes. Here, the authors show that Atg40 is clustered by interaction with Atg8 to generate local membrane curvature and promote autophagosome packing.

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Autores principales:	Keisuke Mochida, Akinori Yamasaki, Kazuaki Matoba, Hiromi Kirisako, Nobuo N. Noda, Hitoshi Nakatogawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b661a782e7a349a3ac3c2d7882684247
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spelling	oai:doaj.org-article:b661a782e7a349a3ac3c2d78826842472021-12-02T14:34:13ZSuper-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes10.1038/s41467-020-17163-y2041-1723https://doaj.org/article/b661a782e7a349a3ac3c2d78826842472020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17163-yhttps://doaj.org/toc/2041-1723The ER is subject to autophagy (ER-phagy) for turnover, with Atg40 acting as a receptor to sequester ER with Atg8 in autophagosomes. Here, the authors show that Atg40 is clustered by interaction with Atg8 to generate local membrane curvature and promote autophagosome packing.Keisuke MochidaAkinori YamasakiKazuaki MatobaHiromi KirisakoNobuo N. NodaHitoshi NakatogawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keisuke Mochida Akinori Yamasaki Kazuaki Matoba Hiromi Kirisako Nobuo N. Noda Hitoshi Nakatogawa Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
description	The ER is subject to autophagy (ER-phagy) for turnover, with Atg40 acting as a receptor to sequester ER with Atg8 in autophagosomes. Here, the authors show that Atg40 is clustered by interaction with Atg8 to generate local membrane curvature and promote autophagosome packing.
format	article
author	Keisuke Mochida Akinori Yamasaki Kazuaki Matoba Hiromi Kirisako Nobuo N. Noda Hitoshi Nakatogawa
author_facet	Keisuke Mochida Akinori Yamasaki Kazuaki Matoba Hiromi Kirisako Nobuo N. Noda Hitoshi Nakatogawa
author_sort	Keisuke Mochida
title	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
title_short	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
title_full	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
title_fullStr	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
title_full_unstemmed	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
title_sort	super-assembly of er-phagy receptor atg40 induces local er remodeling at contacts with forming autophagosomal membranes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b661a782e7a349a3ac3c2d7882684247
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Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

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