MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibi...

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Autores principales:	Stephan Lange, Katja Gehmlich, Alexander S. Lun, Jordan Blondelle, Charlotte Hooper, Nancy D. Dalton, Erika A. Alvarez, Xiaoyu Zhang, Marie-Louise Bang, Yama A. Abassi, Cristobal G. dos Remedios, Kirk L. Peterson, Ju Chen, Elisabeth Ehler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b664fe69f60e4479bfe0ab916f7779bf
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spelling	oai:doaj.org-article:b664fe69f60e4479bfe0ab916f7779bf2021-12-02T14:39:49ZMLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy10.1038/ncomms121202041-1723https://doaj.org/article/b664fe69f60e4479bfe0ab916f7779bf2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12120https://doaj.org/toc/2041-1723Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibiting PKCα auto-phosphorylation and function.Stephan LangeKatja GehmlichAlexander S. LunJordan BlondelleCharlotte HooperNancy D. DaltonErika A. AlvarezXiaoyu ZhangMarie-Louise BangYama A. AbassiCristobal G. dos RemediosKirk L. PetersonJu ChenElisabeth EhlerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Lange Katja Gehmlich Alexander S. Lun Jordan Blondelle Charlotte Hooper Nancy D. Dalton Erika A. Alvarez Xiaoyu Zhang Marie-Louise Bang Yama A. Abassi Cristobal G. dos Remedios Kirk L. Peterson Ju Chen Elisabeth Ehler MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
description	Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibiting PKCα auto-phosphorylation and function.
format	article
author	Stephan Lange Katja Gehmlich Alexander S. Lun Jordan Blondelle Charlotte Hooper Nancy D. Dalton Erika A. Alvarez Xiaoyu Zhang Marie-Louise Bang Yama A. Abassi Cristobal G. dos Remedios Kirk L. Peterson Ju Chen Elisabeth Ehler
author_facet	Stephan Lange Katja Gehmlich Alexander S. Lun Jordan Blondelle Charlotte Hooper Nancy D. Dalton Erika A. Alvarez Xiaoyu Zhang Marie-Louise Bang Yama A. Abassi Cristobal G. dos Remedios Kirk L. Peterson Ju Chen Elisabeth Ehler
author_sort	Stephan Lange
title	MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
title_short	MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
title_full	MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
title_fullStr	MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
title_full_unstemmed	MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
title_sort	mlp and carp are linked to chronic pkcα signalling in dilated cardiomyopathy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b664fe69f60e4479bfe0ab916f7779bf
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MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

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