MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibi...

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Bibliographic Details
Main Authors: Stephan Lange, Katja Gehmlich, Alexander S. Lun, Jordan Blondelle, Charlotte Hooper, Nancy D. Dalton, Erika A. Alvarez, Xiaoyu Zhang, Marie-Louise Bang, Yama A. Abassi, Cristobal G. dos Remedios, Kirk L. Peterson, Ju Chen, Elisabeth Ehler
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/b664fe69f60e4479bfe0ab916f7779bf
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