Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors

Meng Zhang, Fuqiang Zhang, Te Liu, Pu Shao, Lian Duan, Jun Yan, Xupeng Mu,* Jinlan Jiang* Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinlan Jiang; Xup...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang M, Zhang F, Liu T, Shao P, Duan L, Yan J, Mu X, Jiang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	stem cell membrane polydopamine nanoparticles chemo-photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b66bb0d5d69046b8a84ed1371ad41769
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b66bb0d5d69046b8a84ed1371ad41769
record_format	dspace
spelling	oai:doaj.org-article:b66bb0d5d69046b8a84ed1371ad417692021-12-02T13:47:45ZPolydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors1178-2013https://doaj.org/article/b66bb0d5d69046b8a84ed1371ad417692020-12-01T00:00:00Zhttps://www.dovepress.com/polydopamine-nanoparticles-camouflaged-by-stem-cell-membranes-for-syne-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Meng Zhang, Fuqiang Zhang, Te Liu, Pu Shao, Lian Duan, Jun Yan, Xupeng Mu,* Jinlan Jiang* Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinlan Jiang; Xupeng MuScientific Research Center, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin, People’s Republic of ChinaEmail jiangjinlan@jlu.edu.cn; muxupeng@jlu.edu.cnPurpose: Nanoparticle (NP)-based chemo-photothermal therapy (CPT) has been shown to be a promising non-invasive approach for antitumor treatment. However, NPs must overcome the limitations of opsonization, clearance of the reticuloendothelial system, and ineffective targeting of tumor tissue sites. To solve these problems, stem cell membrane (SCM)-camouflaged polydopamine nanoparticles (PDA@SCM NPs) carrying the hydrophobic anticancer drug 7-ethyl-10-hydroxycamptothecin (SN38) were constructed for CPT of malignant bone tumors.Methods: We developed umbilical-cord mesenchymal stem cell membrane-coated polydopamine nanoparticles encapsulating SN38 (PDA-SN38@SCM NPs) as an efficient tumor-targeting drug-delivery platform for CPT of malignant bone tumors. We characterized PDA@SCM NPs and evaluated the biocompatibility and anti-phagocytosis properties of PDA@SCM NPs. The antitumor activity of PDA-SN38@SCM NPs was evaluated in MG63 lines and an MG63 xenograft model in mice.Results: Synthesized PDA-SN38@SCM NPs retained an excellent photothermal effect after SN38 loading. The drug release of PDA-SN38@SCM NPs could be triggered by near-infrared irradiation and an acidic stimulus. PDA@SCM NPs exhibited lower nonspecific macrophage uptake, longer retention in blood, and more effective accumulation at tumor sites than that shown by PDA NPs. Confocal laser scanning microscopy (CLSM) and flow cytometry showed that MG63 cells took up more PDA-SN38@SCM NPs than PDA-SN38 NPs. In vitro and in vivo antitumor studies demonstrated the outstanding performance of PDA-SN38@SCM NPs in synergistic CPT for bone tumors.Conclusion: PDA-SN38@SCM NPs demonstrated an extraordinary synergistic CPT effect and could be a promising strategy for the treatment of malignant bone tumors.Keywords: stem cell membrane, polydopamine nanoparticles, chemo-photothermal therapyZhang MZhang FLiu TShao PDuan LYan JMu XJiang JDove Medical Pressarticlestem cell membranepolydopamine nanoparticleschemo-photothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10183-10197 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell membrane polydopamine nanoparticles chemo-photothermal therapy Medicine (General) R5-920
spellingShingle	stem cell membrane polydopamine nanoparticles chemo-photothermal therapy Medicine (General) R5-920 Zhang M Zhang F Liu T Shao P Duan L Yan J Mu X Jiang J Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
description	Meng Zhang, Fuqiang Zhang, Te Liu, Pu Shao, Lian Duan, Jun Yan, Xupeng Mu,* Jinlan Jiang* Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinlan Jiang; Xupeng MuScientific Research Center, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin, People’s Republic of ChinaEmail jiangjinlan@jlu.edu.cn; muxupeng@jlu.edu.cnPurpose: Nanoparticle (NP)-based chemo-photothermal therapy (CPT) has been shown to be a promising non-invasive approach for antitumor treatment. However, NPs must overcome the limitations of opsonization, clearance of the reticuloendothelial system, and ineffective targeting of tumor tissue sites. To solve these problems, stem cell membrane (SCM)-camouflaged polydopamine nanoparticles (PDA@SCM NPs) carrying the hydrophobic anticancer drug 7-ethyl-10-hydroxycamptothecin (SN38) were constructed for CPT of malignant bone tumors.Methods: We developed umbilical-cord mesenchymal stem cell membrane-coated polydopamine nanoparticles encapsulating SN38 (PDA-SN38@SCM NPs) as an efficient tumor-targeting drug-delivery platform for CPT of malignant bone tumors. We characterized PDA@SCM NPs and evaluated the biocompatibility and anti-phagocytosis properties of PDA@SCM NPs. The antitumor activity of PDA-SN38@SCM NPs was evaluated in MG63 lines and an MG63 xenograft model in mice.Results: Synthesized PDA-SN38@SCM NPs retained an excellent photothermal effect after SN38 loading. The drug release of PDA-SN38@SCM NPs could be triggered by near-infrared irradiation and an acidic stimulus. PDA@SCM NPs exhibited lower nonspecific macrophage uptake, longer retention in blood, and more effective accumulation at tumor sites than that shown by PDA NPs. Confocal laser scanning microscopy (CLSM) and flow cytometry showed that MG63 cells took up more PDA-SN38@SCM NPs than PDA-SN38 NPs. In vitro and in vivo antitumor studies demonstrated the outstanding performance of PDA-SN38@SCM NPs in synergistic CPT for bone tumors.Conclusion: PDA-SN38@SCM NPs demonstrated an extraordinary synergistic CPT effect and could be a promising strategy for the treatment of malignant bone tumors.Keywords: stem cell membrane, polydopamine nanoparticles, chemo-photothermal therapy
format	article
author	Zhang M Zhang F Liu T Shao P Duan L Yan J Mu X Jiang J
author_facet	Zhang M Zhang F Liu T Shao P Duan L Yan J Mu X Jiang J
author_sort	Zhang M
title	Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
title_short	Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
title_full	Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
title_fullStr	Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
title_full_unstemmed	Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors
title_sort	polydopamine nanoparticles camouflaged by stem cell membranes for synergistic chemo-photothermal therapy of malignant bone tumors
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b66bb0d5d69046b8a84ed1371ad41769
work_keys_str_mv	AT zhangm polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT zhangf polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT liut polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT shaop polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT duanl polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT yanj polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT mux polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors AT jiangj polydopaminenanoparticlescamouflagedbystemcellmembranesforsynergisticchemophotothermaltherapyofmalignantbonetumors
_version_	1718392518463193088

Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors

Ejemplares similares