The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.

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Autores principales: Kun Zhang, Xiaohui Han, Zhen Zhang, Lina Zheng, Zhimei Hu, Qingbin Yao, Hongmei Cui, Guiming Shu, Maojie Si, Chan Li, Zhemin Shi, Ting Chen, Yawei Han, Yanan Chang, Zhi Yao, Tao Han, Wei Hong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b66f68f91b7c4a3abba46dae2622e5e1
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spelling oai:doaj.org-article:b66f68f91b7c4a3abba46dae2622e5e12021-12-02T13:27:30ZThe liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways10.1038/s41467-017-00204-42041-1723https://doaj.org/article/b66f68f91b7c4a3abba46dae2622e5e12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00204-4https://doaj.org/toc/2041-1723Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.Kun ZhangXiaohui HanZhen ZhangLina ZhengZhimei HuQingbin YaoHongmei CuiGuiming ShuMaojie SiChan LiZhemin ShiTing ChenYawei HanYanan ChangZhi YaoTao HanWei HongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kun Zhang
Xiaohui Han
Zhen Zhang
Lina Zheng
Zhimei Hu
Qingbin Yao
Hongmei Cui
Guiming Shu
Maojie Si
Chan Li
Zhemin Shi
Ting Chen
Yawei Han
Yanan Chang
Zhi Yao
Tao Han
Wei Hong
The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
description Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.
format article
author Kun Zhang
Xiaohui Han
Zhen Zhang
Lina Zheng
Zhimei Hu
Qingbin Yao
Hongmei Cui
Guiming Shu
Maojie Si
Chan Li
Zhemin Shi
Ting Chen
Yawei Han
Yanan Chang
Zhi Yao
Tao Han
Wei Hong
author_facet Kun Zhang
Xiaohui Han
Zhen Zhang
Lina Zheng
Zhimei Hu
Qingbin Yao
Hongmei Cui
Guiming Shu
Maojie Si
Chan Li
Zhemin Shi
Ting Chen
Yawei Han
Yanan Chang
Zhi Yao
Tao Han
Wei Hong
author_sort Kun Zhang
title The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
title_short The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
title_full The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
title_fullStr The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
title_full_unstemmed The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
title_sort liver-enriched lnc-lfar1 promotes liver fibrosis by activating tgfβ and notch pathways
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b66f68f91b7c4a3abba46dae2622e5e1
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